清热消银汤联合穴位埋线治疗血热型寻常型银屑病的疗效观察和对T细胞亚群的影响.pdfVIP

提 要 目的：观察清热消银汤联合穴位埋线治疗血热型寻常型银屑病的临床疗效及对T 细胞亚群的影响，探讨清热消银汤联合穴位埋线治疗血热型寻常型银屑病的作用机 理。 方法：将80例血热型寻常型银屑病患者随机分成治疗组和对照组2组。其中， 治疗组43例，内服清热消银汤联合穴位埋线，对照组37例，内服复方青黛丸，疗程 8周。通过观察皮损分布范围、红斑严重程度、鳞屑多少、浸润程度及瘙痒程度等的 变化来判定疗效。同时观察治疗前后外周血T细胞亚群的变化。 结果：治疗组痊愈率74.42％，总有效率93.02％；对照组痊愈率45.95％，总 有效率 78.38 ％，两组比较差异均有统计学意义（P0.05）。T细胞亚群检测结果，治 疗前，患者外周血T淋巴细胞亚群（CD3+、CD4+、CD4+/CD8+）低于正常范围，CD8+ 测定值高于正常范围，清热消银汤联合穴位埋线治疗后，20例患者外周血CD3+、CD4+ 细胞数及CD4+/CD8+比值升高并能恢复于正常，CD8+细胞数治疗前后无明显变化。 结论：清热消银汤联合穴位埋线治疗血热型寻常型银屑病疗效确切，复发率低， 其作用机理可能与调节免疫、抗病原微生物、抗炎、抗氧化作用、改善血液流变学等 有关。 关键词 血热型寻常型银屑病；清热消银汤；穴位埋线；T细胞亚群；临床研究 The clinical study of Qingrexiaoyintang combining catgut implantation at acupoint treating psoriatic of blood-heat type and its influence on T cell subsets Specialty:Dermatology,Surgery of TCM Tutor:Professor Zhang Xiaojie Author:Zhang Dongmei Abstract Objective: To observe the clinial effect of Qingrexiaoyintang combining catgut implantation at acupoint treating psoriatic of blood-heat type and study the infulence of this therapeutic method on T cell subsets,probe into its mechanism . Method: 80 cases of psoriasis vulgaris are randomized into two groupstreatment group (Qingrexiaoyintang combining catgut implantation at acupoint group)and control group (Fufangqingdaiwan group).during the 8-week treatment course,observeing the skin distribution range,erythema severity,scale thickness,soakage degree,itching degree and so on,to determine the effect. T cell subsets were observed before and after treatment . Result: Clinical Research ：the healing rate and total effective rate of the treatment group are 74.8% and 91.2% respectively while that of the control group a