炎症细胞因子及糖尿病肢体动脉闭塞症中医证型的相关性研究.pdfVIP

提 要 目的：探讨炎症细胞因子超敏 C-反应蛋白(hsCRP)、肿瘤坏死因子- α(TNF- α) 、 白介素6(IL-6)、白介素 10(IL-10)在湿热下注型、血瘀型糖尿病肢体动脉闭塞症(DAO) 患者和健康人之间的差异，分析其与 DAO 中医辨证分型的相关性。方法：测定 30 例湿热下注型 DAO 患者(A 组) 、30 例血瘀型 DAO 患者(B 组)和 30 例健康人(C 组) 的各炎症细胞因子水平，同时测定其内皮素(ET-1)、一氧化氮(NO)水平，对观察指标 进行统计学分析。结果：A 组、B 组各炎症细胞因子、ET-1 水平明显高于 C 组，NO 水平明显低于 C 组；A 组各炎症细胞因子、ET-1 水平明显高于 B 组，NO 水平在 A 、 B 两组之间无明显差异。结论：DAO 患者存在着炎症细胞因子的过度激活，并与中 医证型密切相关，提示炎症细胞因子可作为 DAO 中医辨证分型的重要客观化指标。 关键词 糖尿病肢体动脉闭塞症；湿热下注型；血瘀型；炎症细胞因子 Research on the Relation between Inflammatory Cells and Familiar Syndrome Differentiation of TCM in Patients with Diabetic Arterial Occlusion of Lower Extremities Specialty：Peripheral Vascular Diseases ，Surgery of TCM Author ：Mao Junjun Tutor：Prof. Hou Yufen Abstract Objectiv ：Through exploreing the difference of hsCRP，TNF- α，IL-6 and IL-10 bentween 30 healthy people and 80 patients with Diabetic Arterial Occlusion of Lower Extremities ， among whom 50 were attributed to the syndrome of pathogenic dampness-heat(A)，and 30 were attributed to the syndrome of blood stasis(B) to analyse relevance of inflammatory cells and differentiation of symptoms and signs of TCM ．Method ：The author has measured level of hsCRP ，TNF- α，IL-6 and IL-10 in 30 healthy people and 80 patients with DAO ，among them 50 patients were allocated to pathogenic dampness-heat attacking the lower limb (A) and the others to the syndrome of blood stasis (B) ．At the same time ，she has measured level of endothelin (ET) and nitric oxide (NO) and carry on statistical analysis separately ．Result ：The levels of hsCRP，TNF- α，IL-6，IL-10，ET and NO in group A and B were higher than that in group C. The levels of hsCRP，TNF- α，IL-6，IL-10 and ET in group A were higher than that in group B ．But the levels of NO in the