熄风通络化痰汤治疗急性缺血性中风临床探究.pdfVIP

提 要 目的：观察熄风通络化痰汤治疗急性缺血性中风的临床疗效，探索其作用机制， 以期寻求治疗急性缺血性中风的新思路及有效方药。 方法：将 60 例急性缺血性中风患者随机分为熄风通络化痰汤治疗组和西药对照 组，治疗 28 天。通过观察治疗前后患者神经功能缺损积分、日常生活能力积分、伴 随症状、血脂、脑血流动力学、神经原特异性烯醇化酶的变化，观察熄风通络化痰汤 治疗急性缺血性中风的疗效，并探讨其作用机理及急性缺血性中风与神经原特异性烯 醇化酶的关系。 结果：28 天后治疗组与对照组的神经功能缺损指标均改善明显，治疗组与对照 组对中风急性期的治疗均有效，但治疗组与对照组治疗后神经功能缺损评分差值的比 较经统计学处理 P0.05，有显著性差异，说明治疗组治疗急性期中风的疗效优于对 照组；急性缺血性中风病情程度与NSE水平呈显著正相关。 结论：熄风通络化痰汤对风痰瘀阻型急性脑梗塞患者有良好的治疗效果，对患者 远期的功能恢复，也将起到积极的治疗意义，熄风通络化痰汤值得在临床上进一步推 广运用。 关键词 急性缺血性中风；风痰瘀阻证；熄风通络化痰汤；临床研究 Clinical Research on Treatment of Acute Ischemic Stroke (AIS) with “Xifeng Tongluo Huatan Decoction” Speciality: Internal Medicine of TCM Author: Liu Yuanxiang Tutor: Prof.Hu Zhiqiang Abstract Objective：To observe the clinical effect and the mechanism of the treatment of AIS with “Xifeng Tongluo Huatan Decoction”, in order to approach to a new thought and effective herbs on AIS. Methods: All 60 patients of AIS were randomly divided into two groups: the treatment group of “Xifeng Tongluo Huatan Decoction” and the control group of western medicine. Tests were performed from 28th day after treatment. By analyzing the changes of neurological function defect scale (NFD), Barthel index, accompany symptoms and sighs, blood-lipid, cerebral hemodynamics and NSE, we observed the clinical effect and the mechanism of the treatment AIS with “Xifeng Tongluo Huatan Decoction”, and explored the relation between AIS and NSE. Result: After 28 days’ treatment, the NFD of two groups had obviously been improved, and the treatment of in the acute period of stroke was both effective. By statistical analysis, the difference of NDF