疏肝及胃散治疗胆汁反流性胃炎的临床研究.pdfVIP

提 要 目的:观察中药方疏肝和胃散治疗胆汁反流性胃炎(BRG)的临床疗效。 方法：采用随机对照法，将符合纳入标准的病例60例随机分为治疗组和对照组， 治疗组 30例，对照组 30 例。治疗组服用疏肝和胃散煎剂，对照组服用胆胃康胶囊。 疗程:4周为l疗程，均于治疗前及服药1个疗程后进行疗效比较。 结果:治疗后两组总体疗效及主要症状、体征疗效比较，治疗组均明显优于对照 组（P＜0.01或P＜0.05)。在改善胆汁反流及胃粘膜炎症等方面，治疗组优于对照组 （P＜0.05）。 结论：疏肝和胃散对胆汁反流性胃炎的临床疗效好，未见毒副作用。其治疗机理 可能是通过促进胃排空、协调胃及十二指肠运动，抗炎、抗溃疡、保护胃粘膜等作用 实现的。研究结果从临床角度验证了疏肝和胃散治疗胆汁反流性胃炎的实用性和可行 性，且有进一步研究和探讨的价值。 关键词 疏肝和胃散；胆汁反流性胃炎；临床研究 Clinical Study on Shuganheweisan in Treating Bile Reflux Gastritis Specia1ity:Internal medicine of traditional Chinese medicine Author:Yang guoxiang Tutor:Professor Liu weiming Abstract Objective: To observe the clinical curative effect of shuganhewei san in treating bile reflux gastritis (BRG). Methods: The randomized controlled method was adopted. The selected cases were randomly divided into two groups:treatment groups and contorl groups.30 patients in treatment group were treated with Shuganheweisan, and patients in control group were treated with Danweikang Capsule. Treatment: All patients were treated for four weeks. The changes of primary clinical symptoms and signs in all cases were observed and given evaluation after treatment. Result: The curative effect of the therapy group were obviously better than that of the contorl group(P＜0.01orP＜0.05). Conclusions: Shuganheweisan is a effective formular to cure BRG. No significant toxic and side effect and adverse reactions are observed. The mechanism of the formular is probably to promote gastritis emptying ，harmonize stomach-duodenal,anti-gastritis, anti-ulcer and protect the stomach. This finding authenticated the clinical utility and feasibility o