糖肾平治疗早期糖尿病肾病的临床探究.pdfVIP

提 要 目的：本研究旨在观察具有健脾益肾、化瘀泄浊通络作用的中药煎剂（糖肾平） 对早期糖尿病肾病（DN）的治疗作用，并进一步探讨其作用机制，为临床应用提供可 靠的依据。 方法：将临床诊断为早期糖尿病肾病的患者 69 例随机分为两组，其中中西医结 合治疗组33例，给予中药糖肾平联合西药洛汀新治疗，西药治疗组36例，给予西药 洛汀新治疗，两组均以3个月为一疗程。分别观察两组患者治疗前后症候变化，测量 治疗前后血压的变化，检测用药前后空腹血糖（FPG）、糖化血红蛋白（HbA1C）、总胆 固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇 （LDL-C）、超敏C反应蛋白（hs-CRP）、血浆内皮素（ET）、血清一氧化氮（NO）、24 小 时尿微量白蛋白排泄率（UAER），并做血、尿、大便常规以及肝、肾功能检查，进行 统计分析，判断疗效及用药安全性。 结果：临床观察发现，糖肾平能有效改善早期糖尿病肾病患者的症候，显著降低 hs-CRP、ET、NO和 UAER。治疗前后患者的血、尿、大便常规，肝、肾功能无明显变 化，具有良好的疗效和安全性。 结论：临床研究结果表明，以健脾益肾、化瘀泄浊通络为治则拟定的糖肾平能有 效地治疗早期糖尿病肾病，值得进一步深入研究和临床推广应用。 关键词 糖肾平；NO；ET；hsCRP；早期糖尿病肾病 Clinical Research of Tangshen Ping treat early diabetic nephropathy Speciality: Hormonology of TCM Author: Wang Tijing Tutor: Prof.Zhang Dexian Abstract Objective: This study was designed to observe the preventive and therapeutic effect of early diabetic nephropathy of Tangshen ping with Jianpi Yishen, Huayu Xiezhuo Tongluo Chinese herbs,and to further explore its mechanism,in order to provide reliable clinical application basis. Methods: 69 cases of early diabetic nephropathy patients were randomly divided into two groups,33 cases combined Chinese herbs Tangshen ping and modern medicine Lotensin treatment group,36cases be treated with Lotensin western medicine;both groups are treated 3 months for one course of treatment.Before and after treatment,patients of the two groups were respectively observed in with symptoms,signs,the fasting plasma glucose (FPG),glycosylated hemoglobin (HbA1C),total cholesterol (TC),triglyceride (TG), high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C),high-sensitivity C-reactive protein (hs-CRP), plasma endothelin (ET),serum nitric oxi