补肾解毒合剂治疗慢性乙肝病毒携带的临床探究.pdfVIP

提 要 目的：观察补肾解毒合剂对肝肾阴虚、湿毒内蕴证型慢性乙型肝炎病毒（HBV） 携带者疗效的影响，评价中药复方治疗慢性HBV携带者的临床疗效。 方法：临床以68例慢性HBV携带者为研究对象，随机分为试验组45例（补肾解 毒合剂组）和对照组 23 例（肌苷片﹢维生素 C 片治疗组）。观察患者治疗 24 周后的 临床证候、生化指标、病毒学指标、生活质量等的改善情况。 结果：治疗 24 周时试验组总有效率 35.56%，对照组为 4.35%，总疗效试验组优 于对照组(P 0.05)，差异有统计学意义。试验组在改善中医证候、HBV-DNA转阴率、 抗病毒应答率方面明显优于对照组，有统计学差异(P 0.05)；生存质量方面，在躯 体健康、躯体角色功能、精力、社会机能及心理健康5个维度改善方面亦有统计学差 异；而在HBeAg转阴率、HBeAg/HBeAb转换率方面，两组比较虽无统计学差异，试验 组仍表现出一定的治疗优势。 结论：补肾解毒合剂治疗肝肾阴虚、湿毒内蕴证的慢性HBV携带安全有效，一定 程度上改善患者临床证候及生活质量、提高抗病毒的应答率。 关键词 补肾解毒合剂；慢性乙肝病毒携带；生活质量；肝肾阴虚、湿毒内蕴证 Efficacy Observation on the Treatment of Chronic hepatitis B virus carriers by Bushenjiedu Decoction Speciality:Clinical Study of TCM Author:Yang Jinglin Tutor: Pro.Sun Jianguang Abstract Purpose ： To observe the clinical efficacy of Chinese medicine compound in treating Chronic hepatitis B virus carriers,by the effect of Bushen Jiedu Decoction on Chronic hepatitis B virus carriers as the entry point 。 Method ： As a subject of study of 68 patients with Chronic hepatitis B virus carriers were randomly divided into two groups. The experimental group （45 cases ）was treated with Bushen Jiedu Decoction, and the control group （23 cases ）was treated with Inosine tablets and Vitamin C tablets. After the treatment of 24 weeks, to observe the improvement in patients following as: clinical symptom, biochemical indicators, Pathogen indicators, quality of life and so on. Results ：After the treatment of 24 weeks, the total efficiency in the experimental group was35.56%, which was higher than in the control group 4.35%. Statistically, there was difference between the two groups (P0.05). The experimental group was significantly better than the control group in improving cl