补肾活血法在型糖尿病骨质疏松中的应用.pdfVIP

提 要 目的：评价加味糖骨康治疗糖尿病骨质疏松的临床效果并探讨其疗效机制，为糖 尿病骨质疏松的治疗找到一种安全、方便、有效的途径。 方法：病例来源于山东省中医院内分泌门诊、住院病人及千佛山医院门诊的2型 糖尿病伴骨质疏松患者 70 例。给予随机分为两组，治疗组 35 例，对照组 35 例。治 疗组服用加味糖骨康,对照组服用仙灵骨葆。三个月后观察比较两组临床症状、空腹 及餐后2小时血糖、糖化血红蛋白、血钙（Ca）、血磷（P）、雌二醇（E2）、睾酮（T） 及骨密度（BMD）水平治疗前后各项指标的变化，并采用SPSS16.0软件系统进行数据 统计。 结果：两组药物均对糖尿病骨质疏松症有明显的疗效，但服用加味糖骨康的治疗 组在治疗糖尿病骨质疏松的各方面数据均优于服用仙灵骨葆的对照组,加味糖骨康还 可以提高血中性激素水平。 结论：加味糖骨康治疗糖尿病骨质疏松的疗效确切，能有效减轻、改善骨质疏松 引起的骨痛等一系列的症状，降低空腹及餐后血糖、糖化血红蛋白，提高血中性激素 （E2 、T）水平，与仙灵骨葆均显出明显优势。加味糖骨康作用机理可能是通过雌二 醇（E2）、睾酮（T）来改善骨代谢，从而提高骨密度，达到防治糖尿病骨质疏松的目 的。 关键词 加味糖骨康；2型糖尿病骨质疏松；临床观察。 Clinical Research on Treating Type 2 Diabetes Combined Reduction in bone mass with modified tangukang Speciality: Internal Medicine of TCM Tutor: prof.zhangjuan Author:wushuang Abstract Objective: Evaluation of modified tangukang treatment the clinical effects of osteoporosis and to explore the mechanism of its efficacy for the treatment of diabetes with osteoporosis, , find a safe, convenient and effective way. Methods: Chinese medicine hospital in Shandong Province and Shandong Province Qianfoshan endocrine outpatient and inpatient hospital with type 2DM patients with osteoporosis.70 Patients were randomly divided into two groups, the treatment group, 35 patients ,control group 35 patients. The treatment group taking modified tangukang, the control group was given xianlinggubao capsule observe and compare the two groups after three months of clinical symptoms, fasting and postprandial blood glucose, gyrated hemoglobin, bone metabolic markers, sex hormone levels and changes in bone mineral density before and after treatment, and observed data were statistically analyzed. Results: Two groups of drugs are diabetic os