补肾方药干预老年人高血压病肾气亏虚证性激素水平的探究.pdfVIP

提 要 本研究出自于国家自然科学基金项目“补肾方药干预老年人高血压病肾气亏虚证 性激素受体表达及调控机制的研究”（No.）。 目的：探讨性激素平衡紊乱与老年人高血压病肾气亏虚证发病的相关性，研究经 补肾方药（益肾降压颗粒）干预后，老年人高血压病肾气亏虚证患者性激素水平的变 化；同时探讨补肾方药对此型高血压病患者的临床疗效。方法：收集年龄在 65～75 岁之间，患有 1、2 级高血压病并符合肾气亏虚证或肝火上炎证的辨证标准者；选择 理化检查均正常的健康老年人作为正常对照，每组 40 例，其中男性 20 例、女性 20 例，对以上 3 组人群进行对照研究。采用放射免疫分析法比较 3 组受试者性激素水平 的差异；另外对符合入选标准的老年人高血压病肾气亏虚证患者男女各 20 例，给予 益肾降压颗粒治疗 4 周，观察治疗前后患者性激素水平的变化及临床疗效。结果：与 健康老年人和肝火上炎证患者相比，老年人高血压病肾气亏虚证患者存在性激素平衡 紊乱的情况；益肾降压颗粒不仅能双向调节性激素水平、改善性激素紊乱，还能有效 降压、缓解临床症状。结论：性激素平衡失调是老年人高血压病肾气亏虚证发生的重 要病机，可作为其病因推测及客观化证型诊断的参考；益肾降压颗粒是治疗老年人高 血压病肾气亏虚证的有效复方。 关键词 老年人高血压病；肾气亏虚证；性激素；益肾降压颗粒；临床研究 Research on Invigorate kidney qi-deficiency intervention the level of sex hormones of Elderly hypertension by kidney deficiency syndrome Specialty:The study of cardiovascular diseases,Internal medicine of TCM Author:Jiang Ting Tutor:Professor Guo Weixing Abstract The study comes from the national natural science foundation “qi-deficiency intervention filling kidney deficiency elderly hypertension syndrome sex hormone receptor case kidney-qi express and control mechanism research” . Objective:Explore the relevance between elderly hypertension level of sex hormones and kidney deficiency syndrome and study the invigorate kidney qi-deficiency interention in hypertensive patients with kidney deficiency syndrome level changes sex hormones and clinical curative effect. Methods: Collect age 65 to 75 in between with 1, 2 levels, with hypertension and kidney deficiency syndrome or the inflammation of syndrome differentiation suffered the standards, the choice of chemical check all normal as normal controls the healthy elderly, 40 cases in each group( Every 20 cases male and female )above 3 groups contr