补肾健脾化痰治疗糖尿病高血压的临床探究.pdfVIP

提 要 目的：观察以补肾健脾化痰为治法组成的中药汤剂平消祛眩汤对2型糖尿病合并 高血压患者的临床疗效并探讨其作用机制。 方法：60例2型糖尿病伴有高血压的患者被随机分为治疗组和对照组，每组均为 30例。所选患者均进行糖尿病教育及运动疗法，并给予低糖低脂低钠饮食，口服格列 美脲片（2mg，qd）和二甲双胍(0.5g,tid)以控制血糖，口服缬沙坦胶囊(80mg,qd) 以调控血压。治疗组在上述基础治疗外，另加服中药平消祛眩汤煎剂；对照组仅给予 上述基础治疗。观察治疗前后临床症状、体征、血脂、血压、体重指数、内皮功能等 指标的变化。 结果：1.治疗组综合疗效总有效率为90.1%，对照组为72.2%，两组间比较有显著 差异(P0.05)。2.治疗组中医症状改善总有效率为86.8%，对照组为66.8%，两组间比 较有显著差异(P0.05)。3.平消祛眩汤在改善糖尿病高血压患者的血糖、HBA1C、血 脂、血压、BMI、内皮功能方面均有较好疗效，治疗组患者在治疗前后比较有显著差 异(P0.05)，且治疗组和对照组的组间比较有显著差异(P0.05)。 结论：本研究验证了补肾健脾化痰法对糖尿病合并高血压病患者的疗效,为今后 深入研究奠定了理论与实践基础。 关键词 补肾健脾化痰法；2型糖尿病合并高血压；临床研究 The clinical observation of invigorating kidney and invigorating spleen to remove phlem of diabets combined with hypertension Specialty: Internal Medicine of Traditional Chinese Medicine Author: Wang Xue an Tutor: Prof.Xu Yunsheng Abstract Objective: To observe the therapeutic effect and to discuss the mechanism of Ping-Xiao-Qu-Xuan(PXQX) decoction, which is composed according to the principle of invigorating kidney and invigorating spleen to remove phlem , in the treatment of patients with diabetes and hypertension. Design: In this randomized study, a total of 60 patients with diabetes and hypertension were recruited. They were divided into the PXQX and control groups (n=30 each). All the patients were provided to knowledge education of diabetes and exercise therapy; and they were also given the low carbohydrates, low fat and low sodium diet. In the treatment of western medicine, Glimepiride Tablets (2mg ，qd) and metformin (0.5 g, tid) were taken orally to control blood sugar,on the other hand,Valsartan Capsules(80mg,qd) was