补肾健脾法治疗轻度认知功能障碍的临床探究.pdfVIP

提 要 目的：观察自拟方益源复智饮治疗轻度认知功能障碍的临床疗效，并从中医学角 度探讨其病因病机。 方法：参考目前国际公认的轻度认知功能障碍诊断标准，将符合纳入标准的轻度 认知功能障碍患者62例，采用随机对照分组，分为治疗组(30例)和对照组（32例）。 治疗照组服用“益源复智饮”；对照组服用长春胺缓释胶囊(奥勃兰)。3个月为一个疗 程。观察两组患者用药前后简易智能状态检查量表（MMSE）积分，蒙特利尔认知功 能量表（MoCA）积分，中医临床症状积分的变化情况。 结果：治疗组与对照组治疗前后在 MMSE 量表积分、MoCA 量表积分及中医临 床症状积分差异有统计学意义（P0.05）；两组治疗前后差值比较在 MMSE 量表分 值，MoCA 量表分值上无统计学意义（P0.05），但中医临床症状积分差值比较，有 统计学意义（P0.05）；依据中医临床症状疗效评定标准，治疗组与对照组经统计学 检验，两组中医临床症状疗效差异具有统计学意义（P0.05）。 结论：中药汤剂“益源复智饮”能改善 MCI 患者神经心理学量表积分，中医临 床症状，对延缓轻度认知功能障碍的进展有一定的改善作用。 关键词 轻度认知功能障碍 益源复智饮 脾肾两虚 Clinical Study on Treatment of Mild Cognitive Impairment by Bushenjianpi Specialyt: Internal Medicine of TCM-Clinical study on Nerve System Disease Author: Li dingding Tutor: Prof. Sun lijun Abstract Objective:To investigate the clinical efficacy of yiyuanfuzhi self-treatment to mild cognitive impairment，and from the traditional medicine point of view research its etiology of disease ． Methods ：According to the internationlly recognized diagnostic criterion of mild cognitive impairment, selected 62 cases of patients with MCI, randomized grouping, divided into treatment group (n=30) and control group (n=32).30 cases in treated group take Yiyuanfuzhi self-treatment ; 32 cases in control group take Brovincamine. Patients will be observed before and after the scale mini-mental state examination(MMSE) ，The Montreal Cognitive Assessment （MoCA ），the symptoms of traditional chinese medicine(TCM) after 3months course of treatment 。 Results ：In the treatment groupand thecontrol group before and after treatment in MMSE scores ，MoCA scores ，the scores of symptoms of TCM on the difference between statistical significance