补肾抗疏壮骨汤治疗围绝经期妇女骨质疏松症的临床视察.pdfVIP

提 要 目的：观察补肾抗疏壮骨汤治疗围绝经期妇女骨质疏松症的临床疗效，并初步 探讨其作用机理。方法：将 57 例患者随机分成两组：治疗组 28 例，用补肾抗疏壮 骨汤治疗；对照组 29 例，用尼尔雌醇治疗。观察两组患者治疗前后的临床症状和 中医症候的改善情况，以及骨密度、女性内分泌激素、血液流变学和血清钙的变化。 结果：1.治疗组的骨质疏松疗效总有效率为 96.43%，对照组为 82.76%，两组间比 较有显著性差异 (P0.05)。2.治疗组对中医症侯的改善明显优于对照组，有效率 分别为 92.86 ％和 79.31％，两组间比较有显著性差异 (P0.05)。3. 治疗组对改善 血液粘滞状态及增加血清钙含量的作用优于对照组，有显著性差异 (P0.05)。4. 治疗组与对照组均能较好的改善生殖内分泌，提高雌激素水平，治疗前后有显著性 差异（P0.05），组间比较无显著性差异（P0.05）。结论：补肾抗疏壮骨汤能有效 改善生殖内分泌，提高雌激素水平，改善血液粘滞度，增加血清钙含量，对减少围 绝经期妇女的骨量丢失，提高骨矿物质含量密度，防治骨质疏松症具有较好的作用。 关键词 补肾抗疏壮骨汤；围绝经期；骨质疏松症；临床研究 Clinical Research On Treating the Osteoporosis in Perimenopausal Women with the Bu Shen Kang Shu Zhuang Gu Decoction Speciality： Gynecology of TCM Author ： ZhangLiang Tutor ： Lv Mei Abstract Objective: To observe the clinical effection of treating the osteoporosis in perimenopausal women with Bu Shen Kang Shu Zhuang Gu(BSKSZG) Decoction and explore the function mechanism of it. Methods: 57 patients were divided into two groups randomly:the treatment group(28 cases,treated with BSKSZG )and the control group(29 cases,treated with Nilestriol).The changes of clinical symptoms and syndrome of TCM were observed before and after treatment.Meanwhile the bone density,female endocrine hormone and blood rheology ， serum calcium were measured. Result: 1.The osteoporosis effective rate of the treatment group reached at 96.43%, while the control group reached at 82.76%, there was significant difference between the two groups(p0.05).2.The total effective rate of the syndrome of TCM of the treatment group and the control group were 92.86% and 79.31%, there was significant difference between the two groups(p0.05).3. Compared with Nilestriol ,BSKSZG Decoction was more effectively to improve the blood rheology