石墨烯类纳米材料作为药物载体的研究进展及其潜在风险.PDFVIP

DOI: 10.7524/AJE.1673-5897.20170112005 孙小艳, 卢坤, 李奥, 等. 石墨烯类纳米材料作为药物载体的研究进展及其潜在风险[J]. 生态毒理学报, 2017, 12(3): Sun X Y, Lu S, Li A, et al. Application of graphene-based materials as drug carrier materials and their potential risks: a review[J]. Asian Journal of Ecotoxicology, 2017, 12(3): (in Chinese) 石墨烯类纳米材料作为药物载体的研究进展及其潜在风险 1, 2 3 1 3 3 1, * 孙小艳 , 卢坤 , 李奥 , 高士祥 , 毛亮 , 叶新华 1. 南京医科大学第一附属医院，南京 210029 2. 南京市栖霞区医院，南京210033 3. 南京大学环境学院，污染控制与资源化研究国家重点实验室，南京210046 收稿日期：2017-01-12 录用日期：2017-03-10 摘要：石墨烯作为一种新兴的二维碳纳米材料，近年来受到了医学领域科学家的高度关注。 由于石墨烯类纳米材料具有较大的比表面积，易于表面修饰等优点，目前在药物载体方面的 研究发展迅速。随着纳米技术的发展，除了氧化石墨烯外，进一步将还原氧化石墨烯、石墨 烯量子点、石墨烯纳米带等石墨烯类纳米材料作为药物载体应用到医学领域。本文综述了石 墨烯类纳米材料作为药物载体在医学领域的研究进展，并从石墨烯类纳米材料的相关毒性研 究角度，提醒了人们负载药物前后石墨烯类纳米材料的迁移规律对其潜在风险研究的重要性。 关键词：氧化石墨烯、石墨烯量子点、石墨烯纳米带、药物载体、迁移途径、潜在风险 Application of Graphene-based Materials as Drug Carrier Materials and Their Potential Risks: A Review 1,2 3 1 3 3 1, * Sun Xiaoyan , Lu Kun , Li Ao , Gao Shixiang , Mao Liang , Ye Xinhua 1 The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029 2 Nanjing Qixia District Hospital, Nanjing 210033 3 State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210046 Received 12 January 2017 accepted 10 March 2017 Abstract: In the realm of drug delivery, graphene family materials have gained tremendous attention as promising nanocarriers, owing to their distinct characteristics, such as high surface area, enhanced cellular uptake and the possibility to be easily conjugated with many therapeutics, including both small molecules and biologics. Specially, reduced graphene oxide (rGO), graphene quantum dots (GQDs) an