抗血管新生疗法在人类肿瘤的应用（二） - 奇美医院.pdfVIP

Show-Chwan Med J 2004; 5(3-4): 137-148 137 1,3 3 2 3,4 1 2 3 4 anti-angiogenesis therapy tumor burden matrix metallo- proteinase inhibitor 75 12 avastin marimastat interferon thalidomide optimal biologic dose scheduling biologic end points angiogenic profiling surrogate markers anti-angiogenesis therapy 92 1 20 93 9 15 704 138 138 targeted therapy [1, 2] 75