g 蛋白偶联受体在血管发育中的作用 - 生物通.pdfVIP

HEREDITAS (Beijing) 2013 4 , 35(4): 459―467 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2013.00459 G 蛋白偶联受体在血管发育中的作用 李方方, 李文庆, 荆清 , , 200025 血管发育包括血管发生和血管生成两个阶段。近年研究表明, G 蛋白偶联受体广泛参与调控成血管细胞 的分化、迁移和接合, 尖端细胞和柄细胞命运决定, 内皮细胞的增殖、迁移和管腔形成等多个过程。文章以血 管发育中的这些关键事件为主线, 总结了 G 蛋白偶联受体家族成员特别是视紫红质类和卷曲类受体在调节血 管发育方面的最新研究进展。文章着重介绍了斑马鱼作为模式生物在血管发育生物学研究中的独特优势, 并展 望了利用斑马鱼深入开展G 蛋白偶联受体相关研究的广阔前景。 G 蛋白偶联受体; 血管发生; 血管生成; 视紫红质样受体; Frizzled/Smoothened; 斑马鱼 G protein-coupled receptors in vascular development LI Fang-Fang, LI Wen-Qing, JING Qing Key Laboratory of Stem Cell Biology, Institute of Health Sciences , Shanghai Jiao Tong University School of Medicine Shanghai Insti- tutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China Abstract: The vascular development consists of two continuous processes: vasculogenesis and angiogenesis. Some researches showed that G protein-coupled receptors (GPCRs) play important roles in these processes, including the regula- tion of differentiation, migration and coalescence of angioblasts, fate decision of tip and stalk cells, proliferation and migra- tion of endothelial cells and tube formation. For the key events of vasculogenesis and angiogenesis, we summarize the re- cent advance of GPCRs, especially Class A and F. In particular, the advantages, of zebrafish, which has been widely used in developmental biology as a vertebrate model, are introduced. Using zebrafish will bring the great potential and prospect to demonstrate the role of GPCRs in vascular development in the future. Keywords: G protein-coupled receptors; vasculogenesis; angiogenesis; rhodopsin-like receptors; Frizzled/Smoo- thened; zebra