真菌g 蛋白信号调控蛋白的功能研究进展.pdfVIP

微生物学通报 Apr. 20, 2014, 41(4): 712718 Microbiology China © 2014 by Institute of Microbiology, CAS tongbao@ DOI: 10.13344/j.microbiol.china.130317 专论与综述 真菌G 蛋白信号调控蛋白的功能研究进展 赵勇 王云川 蒋德伟 苏浩 杨金奎* ( 650091) 摘 要G 蛋白信号途径是真菌细胞信号转导网络的枢纽，在细胞的各种生物学调控过程中具 有重要作用。G 蛋白信号调控蛋白(Rgulators of G protein signaling, RGS)是一类重要的G 蛋白信 号调控因子，能通过促进G 蛋白 α亚基(Gα)偶联的GTP 水解，使Gα和Gβγ亚基发生聚合， 导致G 蛋白失活，从而迅速关闭与G 蛋白偶联的信号途径。自从第一个RGS 蛋白在酿酒酵母 中被鉴定以来，目前已经有30 多个RGS 蛋白在重要的模式真菌中被报道，包括构巢曲霉、绿 僵菌、稻瘟病菌、玉米赤霉菌、轮枝镰孢菌、新型隐球菌和白色念珠菌等。RGS 蛋白在真菌的 营养菌丝生长、产孢、毒素和色素生产、致病性和有性生殖等过程中发挥着重要作用。本文对 真菌中已报道RGS 蛋白的功能进行了总结，对真菌RGS 蛋白的结构特征和调控机制进行了评 述。 关键词真菌，G 蛋白，G 蛋白信号调控因子(RGS) ，功能，调控机制 Advances in functional research of RGS proteins in fungi * ZHAO Yong WANG Yun-Chuan JIANG De-Wei SU Hao YANG Jin-Kui (Laboratory for Conservation and Utilization of Bio-Resources , Yunnan University, Kunming , Yunnan 650091, China) Abstract: G protein is located in the hub of the cellular signal transduction network, important in regulating the activity of G-protein. Regulators of G protein signaling (RGS) primarily function as GTPase-accelerating proteins (GAPs) that promote GTP hydrolysis by the Gα subunits, thereby inactivating the G protein and rapidly switching off G protein-coupled signaling pathways. Since the first RGS protein was identified from the budding yeast Saccharomyces cerevisiae, more than 30 RGS proteins have been characterized from several typical fungi, such as Aspergillus nidulans, Metarhizium anisopliae , Magnaporthe oryzae , Gibberella zea