polycomb group (pcg)蛋白复合体 - 遗传.pdfVIP

HEREDITAS (Beijing) 2009 10 , 31(10): 977―981 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2009.00977 Polycomb group (PcG)蛋白复合体 1 2 马克学 , 席兴字 1. , 453007; 2. , 453003 Polycomb group (PcG) 蛋白是一组通过染色质修饰调控靶基因的转录抑制子, 从生化和功能上它可以分 成两个主要的核心蛋白复合体PRC1(Polycomb repressive complex 1)和PRC2(Polycomb repressive complex 2) 。 研究发现PcG 蛋白不仅控制个体正确的发育模式, 而且与细胞的增殖、分化和肿瘤发生有关。文章就PcG 蛋白 的组成、作用机制及功能进行综述, 并对PcG 未来的研究方向进行展望。 PcG 蛋白; 转录抑制; 染色质修饰; 干细胞 Polycomb group protein complexes 1 2 MA Ke-Xue , XI Xing-Zi 1. College of Life Sciences, Henan Normal University, Xinxiang 453007, China; 2. Department of Education Sciences, Xinxiang University , Xinxiang 453003, China Abstract: The transcriptional repressors of the polycomb group (PcG) proteins regulate the targeted genes expression through chromatin modifications. They can be separated biochemically and functionally into two major core multiprotein complexes: PRC1 (Polycomb repressive complex 1) and PRC2 (Polycomb repressive complex 2). Studies revealed that PcG proteins were not only crucial for correct execution of developmental programs but also involved in the regulation of cell proliferation, differentiation, and tumorigenesis. This paper summarizes the components of PcG proteins complexes, its silencing mechanisms and biological functions, and discusses the study of PcG proteins in future. Keywords: PcG proteins; transcriptional repression; chromatin modification; stem cell , Polycomb group(PcG) 1 PcG [1] PcG , PcG , Trithorax