微粒的功能及其与糖尿病的研究进展 - new century science press.pdfVIP

/index.php/gjems Global Journal of Endocrinology and Metabolism Studies，2016,Vol.3,No.1 The function of microparticles and the research progress of diabetes and microparticles 1 2 Min-dan Xu , Ke-qin Zhang 1Dept. of Emergency, Tongji Hospital, Tongji University School of Medicine, Shanghai, China 2Dept. of Endocrinology and Metabolism, Tongji Hospital, Tongji University School of Medicine, Shanghai, China Received: Sep 29, 2015 Accepted: Oct 21, 2015 Published: May 03, 2017 DOI:10.14725/gjems.v3n1.a1332 URL:/10.14725/gjems.v3n1.a1332 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract MPs are vesicles released by cells when stimulated by physical (e.g. shear force) or chemical (e.g. agonists) factors, as well as cells undergoing apoptosis or exposed to inflammatory conditions . MPs are 100~1000 nm in diameter, have membrane cytoskeletons, express phosphatidylserine (PS) on the surface, and lack of nuclei. Surface molecules, enzymes, RNA and DNA are conveyed via MPs from origin cells to target cells. As mediators of information transfer, MPs have been proposed to impose pro-inflammatory and pro-coagulant effects in many disease states, such as cancer, venous thromboembolism, arteriosclerosis, and diabetes mellitus. The hypercoagulable state associated with diabetes is well recognized. More T2DM patients have died from thrombotic diseases. The endothelium-derived MPs in diabetic patients were elevated. TF-positive MPs concentration was increased and procoagulant activity of MPs was elevated. It is worth to research the role of MPs in the hypercoagulable state of diabetic patients. Key Words Microparticles; Tissue factor; Diabetes; Hypercoagulable 微粒的功能及其与糖尿病的研究进展