the swiss-prot protein sequence database and its supplement trembl in 2000（swiss-prot蛋白质序列数据库及其补充trembl在2000年）.pdfVIP

© 2000 Oxford University Press Nucleic Acids Research, 2000, Vol. 28, No. 1 45–48 The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000 Amos Bairoch* and Rolf Apweiler1 Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland and 1The EMBL Outstation, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK Received October 12, 1999; Accepted October 13, 1999 ABSTRACT The SWISS-PROT database distinguishes itself from other protein sequence databases by three distinct criteria: (i) annotations, SWISS-PROT is a curated protein sequence database (ii) minimal redundancy and (iii) integration with other databases. which strives to provide a high level of annotation (such as the description of the function of a protein, Annotation its domains structure, post-translational modifications, In SWISS-PROT two classes of data can be distinguished: the variants, etc.), a minimal level of redundancy and core data and the annotation. For each sequence entry the core high level of integration with other databases. Recent data consists of the sequence data; the citation information (bibliographical references) and the taxonomic data (description developments of the database include format and of the biological source of the protein), while the annotation content enhancements, cross-references to additional co