病生大题（Major problems of illness）.doc

病生大题（Major problems of illness） So that the enzymes, receptors and ion channels have dysfunction 3DNA damage 1 nuclear DNA damage between the formation of interstrand crosslinking, thereby limiting the stock solution chain, resulting in DNA replication, transcription, the genetic expression blocked 2 mitochondrial DNA damage to mitochondrial DNA damage can lead to dysfunction of mitochondrial structure and 4 cell matrix damage of oxygen free radicals the enzymatic degradation of hyaluronic acid, collagen crosslinking, so that the cell matrix became loose, loss of elasticity 7, the mechanism of calcium overload induced cell injury High concentration of Ca2+ in the cytoplasm of the 1 mitochondrial dysfunction of mitochondrial uptake of Ca2+ increased, ATP synthesis, ATP synthesis induced by 2 activation of calcium dependent degradation enzymes promote membrane phospholipid hydrolysis, resulting in cell membrane and cell membrane damage; protease and endonuclease can cause cell skeleton and decomposition of nucleic acids, leading to cell damage 3 promoting activity oxygen generating calcium overload activated calcium dependent protease, promote the transformation of xanthine oxidase xanthine dehydrogenase, resulting in the increase of ROS, damage to cell 4 cell damage The pathogenesis of bleeding at 8 and DIC 1 large consumption of clotting substances in the development of DIC, all kinds of coagulation factors and platelet consumption at the same time, because of a sharp reduction in blood coagulation substance, blood coagulation state into the low 2 secondary fibrinolysis coagulation system hyperfunction activate PLn in blood increases on the one hand, they can degrade many clotting factors, resulting in further reducing blood coagulation. On the other hand, it can also cause FDP/FgDP to increase and increase the anti coagulation force and cause bleeding. After 3 microvascular injuries, extensive microvascular thrombosis, microvascular wall due to ischemia, hypoxia an