卡托普利对小儿扩张型心肌病心功能的影响.pdfVIP

· 54· 中国妇幼保健20o8年第23卷 卡托普利对小儿扩张型心肌病心功能的影响 韩燕燕 马青山 杨思睿 吉林大学第一医院儿科 130021 中国图书分类号 IH25．4 文献标识码 A 文章编号 1001-4411(2008)01-0054-02 【摘 要】 目的：探讨血管紧张素转换酶抑制剂 (ACEI)卡托普利对小儿扩张型心肌病 (DCM)心功能的影响。方法： 通过回顾性分析将32例DCM患儿随机分为对照组 (16例)和治疗组 (16例)，比较治疗前后心功能分级以及各项指标的变化： 彩色多普勒超声仪测左心室舒张末期容量 (LVEDV)、左心室收缩末期容量 (LVESV)、左心室射血分数 (EF)、短轴缩短率 (f’S)。结果：①治疗组与对照组心功能分级均较治疗前有显著改善，但治疗组心功能分级明显好于对照组，心功能分级改善程 度 (NYHAd)也好于对照组。②对照组治疗前后LVEDV、LVESV、EF、FS无明显变化 (P均0．05)；治疗组治疗前后LV· EDV、LVESV均显著低于对照组，EF、FS均显著高于对照组，差异均具有显著意义 (P均0，05)。③两组治疗后比较，差异 均具有显著性 (P0．01)。结论：ACEI能够明显改善DCM心功能。 【关键词】 血管紧张素转换酶抑制剂 扩张型心肌病 心功能 ／],J6 Effect of captopril on children with cardiac function of dilated cardiomyopathy HAN Yan—Yan，MA Qing—Shah，YANG Si—Rui．Department ofPediatrics，First Hospital ofJiMin Unive~ity，Chang- chun 130021，Jilin，China [Abstract] OMective：To understand the effect of angiotensin—converting enzyme inhibitor(ACEI)captopril on children with dilated cardiomyopathy(DCM)．Methods：32 children with DCM were randomly divided into 2 groups：ordinary regimen group(n=16) and captopri legimen group(n=16)．Left ventricular end—diastolic volume(LVEDV)and left ventricular end—systolic volume (LVESV)were measured by echocardiogram before and after treatment．Left ventricular ejection fraction(EF)and fractional shortening (FS)were also determined before and after therapy．Results：①The cardiac function were improved in both of the two groups with mole pro- found effect in the captopril treated group．②After therapy，in ordinary regimen group，there was no significant difference in LVEDV， LVESV，EF，FS levels compared with the levels before treatment(P0．05)；in captopri regimen group，the levels of LVEDV and LVESV were significantly decreased，the levels of EF and FS were significantly increased(P0．01)compared with￡k levels ofbefore treatment．③ There wen sign~cam difference between two groups in the levels ofLVEDV，LVESV，EF，FS er treatmen