顺铂与氟尿嘧啶联合放疗治疗晚期鼻咽癌的长期疗效分析（The long-term efficacy of cisplatin and fluorouracil radiotherapy for advanced nasopharyngeal carcinoma）.docVIP

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顺铂与氟尿嘧啶联合放疗治疗晚期鼻咽癌的长期疗效分析（The long-term efficacy of cisplatin and fluorouracil radiotherapy for advanced nasopharyngeal carcinoma）.doc

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顺铂与氟尿嘧啶联合放疗治疗晚期鼻咽癌的长期疗效分析（The long-term efficacy of cisplatin and fluorouracil radiotherapy for advanced nasopharyngeal carcinoma）

顺铂与氟尿嘧啶联合放疗治疗晚期鼻咽癌的长期疗效分析（The long-term efficacy of cisplatin and fluorouracil radiotherapy for advanced nasopharyngeal carcinoma） The long-term efficacy of cisplatin and fluorouracil radiotherapy for advanced nasopharyngeal carcinoma Update date: 12-04 liu yulan liu shikun tang county (central south university xiangya three hospital pharmacy, changsha city 410013) ABSTRACT OBJECTIVE：To evaluate 5-year survival rates and toxicity of chemotherapy (DDP+5-Fu)combined with radiotherapy in patients with advanced nasopharyngeal carcinoma（NPC）.METHODS：Data of 960 patients included in 10 randomized trials were meta-analyzed using heterogeneity test and fixed effect model. RESULTS：The 5-year survival rate is different between the radio-chemotherapy group and the radiotherapy group（OR=2.09,95%CI:1.62~2.70, χ2=31.81,df=1,P＜0.001＝.The 5-year survival rates among the different radio-chemotherapy groups were no significant difference. The difference of toxicity between the radio-chemotherapy group and the radiotherapy group was significant. CONCLUSION：Chemotherapy(DDP+5-Fu) combined with radiotherapy can increase the 5-years survival rate, and the toxicity is improved accordingly. KEY WORDS Nasopharyngeal carcinoma. Meta - analyzed; DDP + 5 - Fu; Survival rate Objective: to evaluate the five-year survival rate and toxicity of the combined chemotherapy combined with radiotherapy for advanced nasopharyngeal carcinoma. Methods: to retrieve to meet the criteria for the 10 randomized controlled clinical trials, first carries on the heterogeneity analysis, after using fixed effect model to the data of 960 patients of 5-year survival rate and toxic effects of Meta analysis. Results: the five-year survival rate of combined radiotherapy for advanced nasopharyngeal cancer was significantly different (OR = 2.09, 95% CI: 1.62 ~ 1.62, chi-square = 1.62, P 0.001); There was no significant difference between subgroups according to subgroup analysis. Toxicity analysis showed that the toxicity o