清华本科课件《细胞生物学》Lecture 4-transport-13 544003044.pdfVIP

Chapter 5 The Movement of Substances Across Cell Membranes 1. Principles of membrane transport 2. Passive transport 3. Active transport 4. Indirect active transport •  Membrane Transport of Small Molecules and the Electrical Properties of Membranes Chapter 5 in the text book 1 1. Principles of membrane transport 2. Passive transport 3. Active transport 4. Indirect active transport 2 1. Principles of membrane transport A. The plasma membrane is a selectively permeable barrier. It allows for separation and exchange of materials between the inside and outside of the cell. B. The protein-free lipid bilayers are highly impermeable to ions. C. The energetics of solute movement: a)  Diffusion is the spontaneous movement of material from a region of high concentration to a region of low concentration. b)  The free-energy change during diffusion of nonelectrolytes depends on the concentration gradient. c)  The free-energy change during diffusion of electrolytes depends on the electrochemical gradient. 3 D. Transport processes within an eukaryotic cell 4 5 v   Solutes cross membrane by simple diffusion v If uncharged solutes are small enough, they can move down their concentration gradients directly across the lipid bilayer by simple diffusion.