类风湿性关节炎患者IL-1、IL-15的水平变化及意义.pdfVIP

870 实用预防医学 2008年6月 第15卷 第 3期 Practical Preventive Medicine，Jun．2008，Vol 15,No·3 文章编号：1006 3110(2008)03 0870 02 类风湿性关节炎患者IL一1、IL一15的水平变化及意义 张含玉 摘要： 目的 研究类风湿性关节炎(RA)患者血清IL一1、IL 15的水平变化及意义。 方法 收集91例RA患 者和45例健康体检者，分别采用放射免疫分析法和ELISA法测定血清IL 1、IL 15的水平。 结果 RA非活动组和 RA活动组的血清IL一1、IL一15水平均明显高于对照组，差异有统计学意义c、P0．05、)。RA活动组的血清 IL 1、IL一 ． 15，~,-tz高于RA非活动组，差异有统计学意义(P0．05)。在 91例RA患者中血清 IL 1、IL一15水平显著相关(r 0．813，P0．05)。 结论 IL一1、IL一15在RA患者的疾病发展过程中发挥着重要作用，同时检测 RA患者中血清 IL 一 1、IL一15的水平，有利于监测 ．RA病情和指导临床治疗。 关键词： 类风湿性关节炎(RA)；IL 1；IL 15 中图分类号：R593．22 文献标识码：A Changes Of IL一1 and IL～15 Levels in Patients with Rheumatoid Arthritis and its Clinical Significance ZHANG Han (Department ofLaboratory 3Iedieine，the Fourth Affi，liated Hospital ofChina Medical University，Shenyang 110161，Liaon- ing) Abstract： Objective To investigate the changes of IL 1 and lL一15 levels in patients with rheumatoid arthritis RA) and its clinical significance． Methods Ninety—one patients with RA and 45 healthy subjects were enrolled in the investiga‘ tion．IL一1 and IL 15 levels were determined by radio immunology measurement ana【lytic technique and ELISA method． Results IL 1 and iL一15 levels in inactive RA group and active RA group were significantly higher than those of control group(P0．05)．Moreover，IL一1 and IL～15 level s in active RA group were higher than those of inactive RA grouP(P 0．05、)．IL 1 level had significant correlation with IL一15 level in these 91 patients with RA(：r=0．813，P0．05)． Conclu— sions Serum IL一1 and IL 15 levels are closely related to the genesis and development of RA．1t is very important of this al_ lied examination for RA earlier diagnosis and giving direction proposal in the treatment of RA． Key words： Rheumatoid a