卤代芳烃的氰基化反应_朱益忠（Zhu Yizhong _ cyanation of aryl halides）.docVIP

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卤代芳烃的氰基化反应_朱益忠（Zhu Yizhong _ cyanation of aryl halides）.doc

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卤代芳烃的氰基化反应_朱益忠（Zhu Yizhong _ cyanation of aryl halides）

卤代芳烃的氰基化反应_朱益忠（Zhu Yizhong _ cyanation of aryl halides） Cyano reaction of halogenated aromatic hydrocarbons Zhu Yizhong.. Cai... Ha Chun * (School of chemical engineering, Nanjing University of Science and Technology, Nanjing 210094) The aromatic cyano compounds were prepared by using potassium ferricyanide as the cyano reagent and palladium acetate as the catalyst. The ratio of raw materials, time and reaction were investigated The influence of reaction conditions, such as temperature and catalyst dosage, on the reaction was confirmed. In n (K4 [Fe (CN) 6].. 3H2O).. N (PhBr)..n (Pd (OAc) 2) 200..1 = 000..1, the reaction temperature is 130. 5 h 1.., reaction conditions, only the conversion rate was 99%, the product cyanobenzene The yield was 95%. Potassium ferrocyanide, a cyano reagent, is non-toxic compared with traditional cyano reagents, without complex pretreatment and cheap. The catalytic system of the cyano reaction is simple and requires no expensive catalyst ligands, the amount of the catalyst is small, and the reaction is simple and the reaction is simple Because of small environmental pollution, it is a preparation method of cyanide aromatics with obvious benefit. Meanwhile, the cyano reaction of other halogenated aromatic hydrocarbons was investigated Both brominated aromatic hydrocarbons and aromatic hydrocarbons can be obtained with good yields: 91% ~ 96%. Keywords cyano, potassium ferrocyanide, aromatic cyano compounds CLC number: O621. 2; O625. 6.... Document ID code: A.... Article number: 1000..0518 (2007) 08..0888..05 2006..08..30 received 2007..01..08 time Contact person: Cai Chun, male, Professor, doctoral supervisor; E..M ai:l C. ca@i m ai.l n just. edu. CN; research direction: fine organic chemicals synthesis Aromatic cyano compounds are important intermediates for organic synthesis. They can be used to hydrolyze aromatic acids and reduce aromatic amines in pesticides and dyes And the medical field is widely used. Traditional cyano reagents have