小儿cpr及其若干进展 - cloudfrontnet.pptVIP

Accompanying mild hypothermia significantly improved the prognosis of septic mice than artificial mild hypothermia Qilian Xie Department of Emergency Anhui Provincial Childrens Hospital Background Hypothermia, a protective treatment method for acute brain damage that has been considered as the only effective method in the 20th century, has now been popularly accepted in clinical practices? Interestingly, Some patients with sepsis are found with accompanying mild hypothermia (ACMH); however, the effects of ACMH on the patients with sepsis are poorly understood. Objective To compare the impacts of ACMH and artificial mild hypothermia (ATMH) on mortality, systemic inflammatory reactions, and organ functions in mice with sepsis. Methods Septic mouse models were induced and divided into ACMH, un-hypothermia, keep normothermia, and ATMH groups.According to the anal temperature and the thermic intervention strategy. The mortality rate, serum levels of tumor necrosis factor?α?(TNF-α), interferon?γ(IFN-γ), and interleukin (IL)-4 and liver and renal functions of the mice in each group were recorded. Liver, lung, and renal tissues of the mice were stained and examined under optic microscope. Methods NC group:normal control group. KN group:keep normothermia group. ACMH group: accompanying mild hypothermia group. ATMH group:artificial mild hypothermia group. UH group:un-hypothermia group. T:anal temperature Results The mortality rate in the ACMH group was the lowest among all the sepsis groups. Increased serum levels of TNF-α, IFN-γ, and IL-4 and impairments of the liver and renal functions were found in the septic mice. The serum levels of TNF-α, IFN-γ, and IL-4 were significantly lower and the liver and renal functions of ACMH group were not impaired significantly as compared with other sepsis groups. Pathological examinations of the lung, liver, and renal tissues showed that the ACMH group were with the lowest pathological