运动和机械载荷通过骨形态发生蛋白对骨代谢的影响 - 中国细胞生物学 .PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2016, 38(4): 455–460 DOI: 10.11844/cj cb.2016.04.0394 运动和机械载荷通过骨形态发生蛋白对骨代谢的影响 张玲莉 郭健民 邹 军* (上海体育学院, 上海200438) 摘要 骨代谢贯穿于生命的始终, 由成骨细胞介导的骨形成和破骨细胞介导的骨吸收无时 无刻不在发生, 构成了骨代谢的主要环节。在骨组织的众多生长因子中, 骨形态发生蛋白(bone morphogenetic protein, BMP)是骨生长的诱导因子, 其骨诱导能力也最强。通过查阅国内外文献后, 该文主要从在体运动干预和离体机械载荷两方面, 详细地阐述了运动和机械载荷通过作用于BMP 影响骨代谢的状况, 发现运动可以增强BMP的表达, 促进骨形成, 改善骨代谢。同时, 也强调了运动 和BMP对骨代谢影响的关系, 发现有效的成骨分化高度依赖生长因子信号和机械载荷刺激。BMP 在将机械载荷转换为生物化学效应的信号通路中起着重要的调节作用。 关键词 骨形态发生蛋白; 运动; 机械载荷; 骨代谢 Exercise and Mechanical Load Influence the Bone Metabolism through Bone Morphogenetic Protein Zhang Lingli, Guo Jianmin, Zou Jun * (Shanghai University of Sport, Shanghai 200438, China) Abstract There has been bone metabolism in life always. Osteoblast mediated bone formation and osteoclast mediated bone resorption are ever-present, constitute the main parts of bone metabolism. Among numerous growth factors of the bone tissue, BMP is the inducing factor of bone growth, at the same time the bone induction capacity is the strongest. According to the literatures world widely, this review mainly summarises in two parts, the exercise intervention in vivo and mechanical load in vitro. It in detail elaborates exercise and mechanical load by acting on BMP affect bone metabolism condition, and finds that exercise can increase the expression of BMP, promote bone formation, improve bone metabolism. At the same time, the review also emphasizes the relationship between exercise and BMP effect on bone metabolism, and indicates that effective osteogenesis differentiation is highly dependent on the growth factor signals and mechanical load. BMP in mechanical load converts to a biochemical e