细胞周期与帕金森病.pdfVIP

中国临床神经科学 2011年第 19卷第3期 Chin J Clin Neurosci 2011,9 (13),321~325, 330 32 1 进 展 细胞周期与帕金森病 黄 杰，王 涛 (华中科技大学同济医学院附属协和医院神经内科430022) 关键词 细胞周期；帕金森病；神经元 摘要 细胞的生长、分化、增殖和死亡过程都受到细胞周期的精确调控。证据表明，终末分化的有丝分裂后神经元在 死亡前经历了细胞周期的激活。神经细胞周期的异常重启参与了包括帕金森病(PD)在内的许多神经退行性疾病的发病。 很多研究也表明PD 神经元的丢失与细胞周期及其相关分子有着密切的联系。异常重启的细胞周期以及随之表达的细胞 周期蛋白能通过多种渠道启动细胞死亡。但细胞周期再激活的具体机制仍不十分明了。因此，对细胞周期调控机制和 细胞周期相关分子的研究能对PD 发病机制的深入探索，以及寻找新的治疗方法产生重大意义。本文将重点讨论细胞周 期及细胞周期蛋白在PD 发病机制中发挥的重要作用。 Cell Cycle and Parkinson ’s Disease H UANG J ie, WAN G Tao Department of Neurology, Union Hospital, Tongj i Medical College, Huazhong University of Science and Technology, Wuhan 430022, China KEY WORDS cell cycle; Parkinson’s disease; neuron ABSTRACT The cell cycle is a delicately manipulated process for the development, differentiation, proliferation and death of cells. Increasing evidence indicates that postmitotic, terminally differentiated neurons active the cell cycle before death . The re-entry of cell cycle may be involved in many neurodegenerative disorders including Parkinson ’s disease (PD). Many studies indicate that neuronal cell death in PD is related to cell cycle and cell cycle molecules. However, the mechanism of neuronal cell cycle re-activation still remains unclear . Aberrant cell cycle and the expression of cell cycle related proteins induce cells down the road towards neuronal death via multiple pathways. Therefore, the study of aberrant cell cycle regulation and cell cycle related molecules in PD may provide important insights into the pathogenesis of PD and also serve as a mean to the novel PD therapeutic strategies. This review will highlight recent data on the important roles of cell cycle and cell cycle related proteins in the pathogenesis of PD. 帕金森病(Parkinson ’s disease ，PD)是一种缓慢进展