地塞米松脂质体壳聚糖胶囊对大鼠结肠炎的药效学研究_李国锋.pdfVIP

　　 a a b a a a a a 李国锋, 陈建海,赖卓胜,王春霞,杨西晓,许重远,杨莉,侯连兵(a.;b., 510515) :　评价地塞米松(DSP)脂质体 干剂壳聚糖胶囊对结肠炎大鼠的治疗作用。 　用2,4, 6-三硝基苯磺酸钠 (TNBS)诱导大鼠结肠炎, 建立髓过氧化酶(MP )、肿瘤坏死因子(TNF-α)、大鼠结肠质量与大鼠质量比值(C/B)和结肠损伤直观 评分值4种反应结肠炎症程度指标的测定方法,观察口服各种DSP 制剂对结肠炎症的治疗作用。　用TNBS 灌肠时可以 成功地制备大鼠结肠炎症模型, 灌肠后第5 天时反映炎症的各种指标均达到最高值;各种DSP 制剂对TNBS 诱导的实验性大 鼠结肠炎均有治疗效果, 而DSP 脂质体壳聚糖胶囊具有最好的治疗作用。　DSP 脂质体 干剂壳聚糖胶囊较DSP 粉剂壳 聚糖胶囊和DSP 溶液对结肠炎具有更好的局部治疗效果, 值得进一步开发研究。 :地塞米松;壳聚糖胶囊;脂质体;结肠炎;药效学 :R965　　　:A　　　:1001-2494(2006)15-1145-05 Effect of Chitosan Capsule Filled with Dexamethasone Liposome Lyophilized Powder on Colitis in Rats a a b a a a a LI Guo-feng , CHEN Jian-hai , LAI Zhuo-shen , WANG Chun-xia , YANG Xi-xiao , XU Zhong-yuan , YANG Li , a H U Lian-bing (a.Clinical Pharmaceutical Department;b.Gastrointestinal Department, Nanfang Hospital, Nanfang Medical University, Guangzhou 510515, China) ABSTRACT: BJECTIVE　To observe the effect of chitosan capsulefilledwith dexamethasone(DSP)liposome lyophilizedpowder on colitis in rats.METH DS　The colitis in ratwasinduced with the coloclysisof 2, 4, 6-trinitrobenzene sulfonic acid(TNBS).The myeloperioxidase (MP ), tumor necrosis factor(TNF-α), the ratio of rat colon weight/rat body weight(C/B)as well as the colon damage score(Score), which were chosen as the index of colitis degree, were determined.These indexeswere used to evaluate the pharmacodynamic action of various DSP dosage forms after their oral administration.RESULTS　The colitiswassuccessfully inducedwith the coloclysis of TNBS and the inflammation was the most severe in the fifth day.All DSP preparations effectively relieved the colitis in rat, while DSP lyophilized liposome capsule showed optimum effect.C NCLUSI N　DSP lyophilized liposome chitosan capsule may be the most helpful in colitis therapy among all DSP dosage