微生物与人类饮食文明.pdf

微生物与人类饮食文明微生物与人类饮食文明 微生物与人类饮食文明微生物与人类饮食文明 ——微生物食品安全微生物食品安全 微生物食品安全微生物食品安全 Instructor Qun Sun 孙群 Phone: 8541-8810 (O) Email: qunsun@scu.edu.cn Office: Life Sciences Bldg. Rm. 704 Call or email me for an appointment 一坨肉的一年一坨肉的一年 一坨肉的一年一坨肉的一年 2014/1/1 – 2014/2/4 Francesco Redi: disprove Spontaneous Generation 1668: Fly - meat experiment Maggots only appeared in the open jar Phase 3: Golden age of microbiology →→ Modern microbiology →→ Father of bacteriology: Robert Koch Father of modern microbiology: Chance favors the prepared mind. Louis Pasteur Sterilizing the contents of the flask Sterile 消毒 If the flask remains upright, no microbial growth will occur If microbes trapped in the neck reach the sterile liquid, growth will occur Typhoid Mary (Mary Mallon) - The Most Dangerous Woman In America! Woman Cook a Walking Typhoid Fever Factory Clostridium botulinum 肉毒梭状芽胞杆菌肉毒梭状芽胞杆菌 肉毒梭状芽胞杆菌肉毒梭状芽胞杆菌 Botulinum toxin for cosmetic 大S肉毒杆菌注射全体验 Mucus Membranes黏膜黏膜 : preferred 黏膜黏膜 entry of pathogen 1. Respiratory Tract 呼吸道 mouth or nose: Easiest and most frequently Common cold 普通感冒, Flu 流感, Tuberculosis 结 核杆菌, Whooping cough 百日咳, Measles 麻 疹,Diphtheria 白喉 2. Gastrointestinal Tract 胃肠道 Enter thru contaminated food, water, fingers hands Salmonellosis 沙门菌感染, Shigellosis 细菌性痢 疾,Cholera 霍乱, Ulcers 溃疡,Botulism肉毒中毒 Shiga toxin – shigellosis 细菌性志贺菌痢疾细菌性志贺菌痢疾 细菌性志贺菌痢疾细菌性志贺菌痢疾 Lyses rRNA in ribosome Death of epithelial cell