卡培他滨治疗老年晚期胃癌临床观察.docVIP

卡培他滨治疗老年晚期胃癌临床观察【摘要】 目的 观察卡培他滨治疗老年晚期胃癌的近期疗效及毒副反应。 方法 我科于2006年12月至2009年12月,应用卡培他滨治疗35例老年晚期胃癌患者,卡培他滨2500 mg/m?2,每日2次口服,第1～14天; 21 d为1周期;连用4个周期后评价疗效。结果 35例患者中CR 0例(0%)、PR 10例(28.57%)、SD 13例(37.14%)、PD 12例(34.29%)。26例相关症状改善。主要毒副反应为手足综合征、腹泻、血白细胞减少、恶心、呕吐、口腔粘膜炎,但程度均较轻,主要为Ⅰ～Ⅱ度, 经对症处理后很快恢复。结论 卡培他滨单药治疗晚期胃癌的效果确切,安全有效,可明显改善患者症状,提高患者的生活质量,毒副反应小,患者可以耐受。 【关键词】 卡培他滨;老年;胃癌/进展期;化学疗法 Clinical oberservation of capecitabine in treatment of advanced gastric cancer for the elderly patients CHEN Zhi-yong, ZHENG Jun-qiong, LUO Jian-wen,et al. Department of Medical Oncology of Longyan No. 1 Hospital, Fujian Medical University,Longyan 364000,China 【Abstract】 Objective To investigate the efficacy and side-effects of capecitabine in treatment of advanced gastric cancer for aged patients. Methods From December 2006 to December 2009, 35 evaluable patients with gastric carcinoma received capecitabine (2500 mg/m?2 po bid) on days 1~14, the cycles were repeated every 21 days and toxicity were evaluated after 4 cycles.Results In 35 evaluable patients, no cases had complete response(0%), 10 cases had partial response(28.57%), 13 cases had stable disease(37.14%), 11 cases with progressive disease(34.29%). 26 cases had got improved symptoms. The major toxicities were extremity Syndrome, diarrhea, myelosuppression and gastrointestinal response, mainly in I or II degree. Patients were able to recover from these side-effects after the suitable treatments. Conclusion Capecitabine is effective and safe for advanced gastric cancer. It can improve aged patients’ living qualities with better symptoms and tolerable side-effects. 【Key words】Capecitabine;The elderly;Gastric carcinoma/progressive stage;Chemotherapy 作者单位:364000福建医科大学附属龙岩市第一医院肿瘤内科 胃癌(Gastric carcinoma) 是人类最常见的恶性肿瘤之一,危害性严重。在全世界范围内,胃癌的发病率位居所有恶性肿瘤的第2位。在我国,胃癌发病率居各种恶性肿瘤之首,特别在65岁以上老年人中有明显的升高, 而且随着年龄的增加而逐渐增加[1]。 老年胃癌患者临床症状无明显特异性, 确诊时多属进展期,化疗是老年患者必须面对的选择。但老年患者随着年龄的增加, 各脏器功能越来越差, 且常常合并多种疾病,这为化疗带来困难。我科于2006年12月至2009年12月,应用卡培他滨单药治疗35例老年晚