微波联合足叶草酯治疗女性尿道内尖锐湿疣.docVIP

微波联合足叶草酯治疗女性尿道内尖锐湿疣[摘要]目的：探讨治疗女性尿道内尖锐湿疣及预防其复发的有效方法。方法：治疗组55例患者先用微波烧灼女性尿道内尖锐湿疣，疣体消除干净及伤口恢复后再用25%足叶草酯酊外涂尿道内；对照组61例患者仅用微波烧灼治疗。最后观察尿道内的疣体清除情况，如发现疣体则用病理检查确证。结果：治疗组痊愈率为92.7%，对照组痊愈率为13.1%，两组差异有显著性意义(P0.01)。结论：微波烧灼联合足叶草酯酊外涂是治疗女性尿道尖锐湿疣并预防其复发的有效措施。 [关键词]尖锐湿疣；微波；足叶草酯 Treatment of Female Intraurethral Condyloma Acuminatum with Microwave and Podophyllin Tincture LI Yong-shuang, ZHANG Zong-hua (Nanshan district chronic diseases Hospital of Shenzhen city，Shenzhen518047,China;Chronic diseases Hospital of Shenzhen city Shenzhen518020,China) [Abstract]Objective:To study the effective method about treating femaleintraurethral condyloma acuminatum and preventing its relapse. Methods:55 patients of treatment group were treated with microwave once first, then, perfusing the urethra with 25% podophyllin tincture weekly for 6 weeks. 61 patients of control group were only treated with microwave once.After 3 months,all patients were observed to find whether to have condyloma body or not in the urethra. Results:The cure rate of treatment group was 92.7%; the cure rate of control group was 13.1%.The result showed significant differese(P0.01). Conclusion:It was an effective method to treat and prevent intraurethral condyloma acuminatum with the microwave and podophyllin tincture perfusion. [Keywords]Condyloma Acuminatum;Microwave; Podophyllin 女性尿道内尖锐湿疣因疣体不易暴露、空间狭小不好操作、部位深在等，治疗很棘手,复发率高,迁延不愈,可达数年之久，是女性尖锐湿疣的治疗难点之一。即往临床上用过多种疗法，如CO2激光、微波[1]、电灼、手术[2] 、氟尿嘧啶(FU)液外涂[3]、足叶草酯外涂[4]、三氯醋酸外涂[5]等治疗, 大多疗效不佳。为探讨有效治疗及预防复发的方法,笔者借鉴他人微波治疗后用氟尿嘧啶液外敷治疗尿道内尖锐湿疣的经验[6],采用微波烧灼并用足叶草酯酊外搽治疗女性尿道内尖锐湿疣患者, 并与单独用微波烧灼治疗对照。现将结果报道如下： 1材料与方法 1.1临床资料 2007年5月～2008年10月在我院门诊就诊的尿道内尖锐湿疣病人116例, 均经临床和病理确诊，且做了膀胱彩超排除了膀胱内疣体生长。年龄16～49岁, 病程数天至2年不等,大多数有复发经历。随机分为两组,治疗组55例先用微波烧灼1次或多次后若如肉眼可见疣体且伤口愈合后再给予25%足叶草酯酊尿道内外搽；对照组61例仅给予微波烧灼治疗。 1.2治疗方法 治疗组先予阴茎根部局麻后,消毒疣体及周围,使用珠海市和佳医疗设备有限公司生产的CYP-Ⅰ型微波综合治疗仪,输出功率2 450 MHz,波长12 cm,功率0～150 W可调,脚踏式起动,治疗电流量40～60 mA, 逐一清除疣体深达基底。为了防止复发可对残存的基底部重新凝固1次, 扩大边缘至2 mm, 深达真皮层。术后外涂碘伏液,1次/d , 连续1 w。复