有机磷杀虫药中毒程度及心肌损伤关系探析.docVIP

有机磷杀虫药中毒程度及心肌损伤关系探析【摘要】 目的 探讨有机杀虫药中毒程度与心肌损伤的关系。方法 对247例不同程度中毒患者血清心肌肌钙蛋白I（CTn-I）和肌酸激酶（CK-MB）同步检测，同时设立40例健康献血员作为对照组，并将实验资料进行统计学分析。结果 重度中毒、中度中毒、轻度中毒和对照组CTn -I阳性率分别为100．00%（126/126）、65．79%（50/76）、17．78%（8/45）、0．00%（0/40），CK-MB活性升高率分别为100．00%（126/126）50%（38/76）、8．89%（8/45）、0．00%（0/40）。组间比较除轻度中毒组CK-MB活性升高率与对照组比较差异无显著统计学意义（P＞0．05），其余各组间差异均有显著统计学意义（P＜0．01）。结论 有机杀虫药中毒程度与心肌损伤有正相关关系。 【关键词】 有机杀虫药；中毒；心肌损伤；CTn-I；CK-MB The relationship between the toxic degrees of organophosphorus insecticides and myocardial injuries．XU Si-fang，WANG Yu-lin．Peixian People′s Hospital，Peixian 221006,China 【Abstract】 Objective To explore the relationship between the toxic degrees of organophosphorus insecticides and myocardial injuries．Methods The serum cardio troponin-I(CTn-I) and creatine kinase-MB(CK-MB) were assayed simultaneously for 247 cases suffered the toxication of organophosphorus insecticides (group A) and 40 cases of health blood donors (group B)． Group A was divided into three subgroups． They are severe，moderate and mild toxication． The laboratory data of the two groups were analysed statistically．Results The positive rates of CTn-I in group A (3 subgroups) and group B were 100．00%(126/126)，65．79%(50/76)，17．78%(8/45)，0．00%(0/40) respectively． The active rates of CK-MB were 100．00%(126/126)，50．00%(38/76)，8．89%(4/45)，0．00%(0/40) respectively． Each of subgroups was campared with group B，but the subgroup of mild toxication，there werent significant differences(P＞0．05)．Conclusion There was a positive relativity between the toxic degrees of organophorsphorus insecticides and myocardial injuries． 【Key words】 Organophosphorus insecticides；Toxication；Myocardial damage；Cardio troponin-I；Creatine kinase-MB 通过对我院近年来收治的247例有机磷杀虫药中毒患者血清心肌肌钙蛋白I（CTn-I）和肌酸激酶（CK-MB）的同步检测，探讨有机磷杀虫药中毒程度和心肌损伤的关系，现将实验结果分析报告如下。 1 资料与方法 1．1 一般资料 247例有机磷杀虫药中毒者均为住院患者，其中重度中毒126例，中度中毒76例，轻度中毒45例。中毒程度的分类符合《内科学》(第5版)要求[1]。 1．2 检验方法 取患者入院次日早晨空腹静脉血约4 ml分别进行CTn-I和CK-MB检测，CTn-I采用固相免疫层析法，检测敏感度0．2 ng/ml，试剂由芬兰AboaTech．