氯吡格雷治疗不稳定型心绞痛临床疗效分析.docVIP

氯吡格雷治疗不稳定型心绞痛临床疗效分析[摘要] 目的:探讨与研究氯吡格雷治疗不稳定型心绞痛的临床疗效,并对其有效性与安全性进行分析评估。方法:选取2008年11月~2009年11月本院住院的不稳定型心绞痛患者170例。将170例患者随机分为治疗组与对照组,其中对照组85例给予常规治疗,治疗组85例在常规治疗基础上给予氯吡格雷进行治疗,观察两组的临床疗效与心绞痛发作次数、ST变化、血小板计数及纤维蛋白原水平等4项指标的变化情况。结果:对照组85例,总有效率为78.8%;治疗组85例,总有效率为82.9%。两组临床疗效经比较,差异有统计学意义(χ2=12.79,P0.05,差异无统计学意义。结论:氯吡格雷治疗不稳定型心绞痛具有疗效好、不良反应少等特点,值得临床广泛使用。 [关键词] 氯吡格雷;不稳定型心绞痛;ST变化;临床疗效 [中图分类号] R972+.3 [文献标识码]B [文章编号]1674-4721(2010)06(a)-064-02 Analysis of clinical healing efficacy of clopidogrel in the treatment of unstable angina pectoris WANG Runlei (The People’s Hospital of Chongzhou City, Sichuan Province, Chongzhou 611230, China) [Abstract] Objective: To investigate and research the clinical healing efficacy of clopidogrel in the treatment of unstable angina pectoris,and to assess its efficacy and safety. Methods: Selected 170 patients with unstable angina pectoris in our hospital from November 2008 to November 2009.The 170 cases were randomly divided into treatment group and control group.85 cases of the control group received conventional treatment,85 cases in the treatment group were treated with clopidogrel.Observed the clinical efficacy and the number of angina attacks,ST changes,platelet count and fibrinogen level changes in four indicators. Results: The total effective rate of the control group was 78.8%,and the treatment group was 82.9%,the difference was statistically significant,χ2=12.79,P0.05). Conclusion: Clopidogrel in the treatment of unstable angina has good efficacy,few adverse reactions,is worthy of widespread use. [Key words] Clopidogrel;Unstable angina pectoris;ST change;Clinical efficacy 不稳定型心绞痛(unstable angina pectoris)简称UAP,是介于稳定型心绞痛和急性心肌梗死之间的一组临床疾病,具有发病急、易变化及病死率高等特点,且不及时治疗处理极易使得病情恶化发展成为急性心肌梗死,从而给患者带来生活的不便。不稳定型心绞痛的发病机制主要是冠状动脉内粥样斑块破裂或裂缝,诱导血小板聚集而形成白色血栓,从而造成不完全性阻塞的发生。氯吡格雷(clopidogrel)是近年来研制的新型抗血小板药物,其具有起效时间短、副作用少等特点[1]。笔者通过观察2008年11月~2009年11月不稳定型心绞痛患者85例在基础治疗的基础上应用氯吡格雷给予治疗,来探讨观察其疗效及安全性。现分析报道如下: 1 资料与方法 1.1 一般资料 选取2008年11月~2009年11月本