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genetherapyforrootavulsionand spinalcordinjuries - 暨南大学学报
第38卷 第1期 暨南大学学报(自然科学与医学版) Vol.38 No.1
2017年2月 JournalofJinanUniversity(NaturalScience&MedicineEdition) Feb. 2017
Genetherapyforrootavulsionand
spinalcordinjuries
ZILUNDUPrinceLM,ZHOULihua
(DepartmentofAnatomy,ZhongshanSchoolofMedicine,SunYatSenUniversity,Guangzhou510080,China)
[Abstract] Rootavulsionandspinalcordinjuriesareveryimportantclinicalentitiesthathavevexed
scientistsandcliniciansforalongtime.Manytreatmentshavebeendesignedandappliedclinicallybut
noneofthemhassuccessfullycuredparalysisorchronicpainthatcomeswiththeseconditionsinthe
clinicalarea.Inpursuitofasolutiontorootavulsionandspinalcordinjuries,genetherapyhasemerged
asapowerfultoolthatcouldpotentiallymitigatetheimpactonpatients,families,healthcareresources
andworldeconomies.Clinicaltrialsinvolvinggenetherapyinotherconditionssuchascancerhave
unravelledalotofpromisesandchallengesthathaveservedaspointerstoguidetheimminentscalingup
ofspinalcordtargetedgenetherapyfromtheexperimentalworktoeverydayclinicalutility.Thisreview
discussestheanatomyandthebrachialplexusrootavulsionofandspinalcordinjuriesrelated
pathobehaviourofthebloodspinalcordbarrier,typesofgenetherapyandthegenecargodeliveryvectors
currentlybeingexploitedinthemanagementofspinalcordinjuries.Majorhighlightsoftheviralandnon
viralgenedeliveryroutesareexploredwhilepointingoutareaswheretheyhavebeenfoundwanting
warrantingmuchmoreexploration.Itisclearthatgenetherapytargetedatthespinalcordhascomea
longwayandstillhasmorebasicscienceresearchneededespeciallyforthepotentiallytransduction
efficientviralvectors.Untilthesafetyanddesignissuesraisedabouttheviralvectorsaretakencareof
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