genetherapyforrootavulsionand spinalcordinjuries - 暨南大学学报.pdfVIP

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genetherapyforrootavulsionand spinalcordinjuries - 暨南大学学报.pdf

genetherapyforrootavulsionand spinalcordinjuries - 暨南大学学报

第38卷 第1期 暨南大学学报(自然科学与医学版) Vol.38 No.1 2017年2月 JournalofJinanUniversity(NaturalScience&MedicineEdition) Feb. 2017   Genetherapyforrootavulsionand spinalcordinjuries ZILUNDUPrinceLM,ZHOULihua (DepartmentofAnatomy,ZhongshanSchoolofMedicine,SunYatSenUniversity,Guangzhou510080,China) [Abstract] Rootavulsionandspinalcordinjuriesareveryimportantclinicalentitiesthathavevexed scientistsandcliniciansforalongtime.Manytreatmentshavebeendesignedandappliedclinicallybut noneofthemhassuccessfullycuredparalysisorchronicpainthatcomeswiththeseconditionsinthe clinicalarea.Inpursuitofasolutiontorootavulsionandspinalcordinjuries,genetherapyhasemerged asapowerfultoolthatcouldpotentiallymitigatetheimpactonpatients,families,healthcareresources andworldeconomies.Clinicaltrialsinvolvinggenetherapyinotherconditionssuchascancerhave unravelledalotofpromisesandchallengesthathaveservedaspointerstoguidetheimminentscalingup ofspinalcordtargetedgenetherapyfromtheexperimentalworktoeverydayclinicalutility.Thisreview discussestheanatomyandthebrachialplexusrootavulsionofandspinalcordinjuriesrelated pathobehaviourofthebloodspinalcordbarrier,typesofgenetherapyandthegenecargodeliveryvectors currentlybeingexploitedinthemanagementofspinalcordinjuries.Majorhighlightsoftheviralandnon viralgenedeliveryroutesareexploredwhilepointingoutareaswheretheyhavebeenfoundwanting warrantingmuchmoreexploration.Itisclearthatgenetherapytargetedatthespinalcordhascomea longwayandstillhasmorebasicscienceresearchneededespeciallyforthepotentiallytransduction efficientviralvectors.Untilthesafetyanddesignissuesraisedabouttheviralvectorsaretakencareof

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