阻塞性睡眠呼吸暂停综合征患者心血管危险因素特征研究.docVIP

阻塞性睡眠呼吸暂停综合征患者心血管危险因素特征研究[摘要] 目的:分析不同程度阻塞性睡眠呼吸暂停综合征(OSAS)患者的心血管危险因素特点。方法:99例OSAS患者按呼吸暂停低通气指数(AHI)分为轻中度组65例(5≤AHI≤40)和重度组34例(AHI40),对两组患者的临床特点和血液学参数等进行比较分析。结果:重度组患者体重指数(kg#8226;m-2)、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、红细胞计数、纤维蛋白原水平均明显高于轻中度组,而高密度脂蛋白胆固醇及左室射血分数低于轻中度组(P0.05)。结论:重度组患者肥胖、血脂代谢紊乱、血液高凝状态均更明显。加强对OSAS高危患者的防治,将有利于降低心血管疾病的风险。? [关键词] 阻塞性睡眠呼吸暂停综合征; 心血管疾病; 危险因子? [中图分类号] R541.4[文献标识码] A[文章编号] 1671-7562(2010)01-0015-04? doi:10.3969/j.issn.1671-7562.2010.01.004?? Characteristics of cardiovascular risk factors in patients with ? obstructive sleep apnea syndrome?? FANG Ying, CHEN Zhong, MA Gen-shan, LIU Ming (School of Clinical Medicine, Southeast University, Nanjing 210009, China)?? [Abstract] Objective: To evaluate the characteristics of cardiovascular risk factors in patients with different severity of obstructive sleep apnea syndrome(OSAS). Methods: According to apnea-hypopnea index(AHI), 99 patients with OSAS were enrolled and divided into mild-moderate group(n=65, 5≤AHI≤40 ) and severe group(?n=34, AHI40). The clinical characteristics and hematology parameter of patients were compared in two groups. Results: Compared with the mild-moderate group, patients in the severe group had higher mean values of body mass index(BMI, kg#8226;m-2), triglyceride, total cholesterol, low-density lipoprotein cholesterol, red blood cell counts and fibrinogen, while levels of high-density lipoprotein cholesterol and left ventricular ejection fraction were lower(P0.05). Conclusion: Patients with severe OSAS are associated with higher values of BMI, red blood cell counts, fibrinogen and more abnormal lipid parameters. Active prevention and treatment of OSAS is in favour of decreasing the future risk of cardiovascular disease.? [Key words] obstructive sleep apnea syndrome; cardiovascular disease; risk factor? 阻塞性睡眠呼吸暂停综合征(OSAS)是一种常见的睡眠障碍性疾病,具有潜在危险性。流行病学资料显示,人群发病率在1%~9%,65岁以上的老年人发病率可达20%~40%[1],在有明确心血管疾病的患者中发病率更高[2]。本研究选取99例诊断为OSAS的住院患者,根据睡眠监测结果,分析不同程度OSAS患者临床心血管危险因素特点和生化等指标