细菌抗生素和重金属协同选择抗性机制研究进展.pdf

生物技术通报 BIO TE CHN OLOG Y B ULLETIN 20 10 5 季秀玲 魏云林 林连兵 ( , 650224) : 随着各类抗生素和新型复合金属材料的不断开发和使用, 境中抗生素和重金属离子协同污染的机率不断提 高, 对 境选择最为敏感的细菌通过自身的进化和发展形成了二者协同选择的抗性机制, 如协同抗性交叉抗性协同调控和 生物膜诱导机制 : 协同抗性 交叉抗性 协同调控 生物膜诱导 R esearch Advances on Coselection R esistantM echanism s of Antibiotic and H eavyM etals R esistance in Bacteria JiX iuling W eiYunlin L in Lianbing (Biotechnology Research Center, Kunm ing University of Science and Technology, K unming 650224) Abstrac:t H eavy m etals and an tibioti are in reasingly found in ba terial habitats due to natural and industrial pro esses, wh i h show ed that a orrelation ex ists between m etal toleran e and antib ioti resistan e in ba teria. They have evolved severalm e hanism s to tolerate the presen e of heavy m etals and antib ioti . These osele tion res istan tm e hanism s in lude oresistan e, rossres istan e, o regulation and biofilm indu tion. K ey w ords: Coresistan e Crossresistan e Coregu lation B iofilm indu tion (Burkholderia cep acia ) [ 4] , , , , , , , , ( Entero acter clo , , acae) [ 5] , (A ero monas) [ 6] , , (M orax ella) (P seudomonas) [ 7 ] , , , , [ 1, 8] ,