纤维细胞平衡因子（Fibroblast balance factor）.docVIP

纤维细胞平衡因子（Fibroblast balance factor） Fibroblast balance factor A polypeptide substance that regulates the growth of cells and other cellular functions by binding to specific and high affinity cell membrane receptors. It exists in platelets and various adult and embryonic tissues and in most cultured cells, and has a certain specificity for different cell types. In general, the growth of cultured cells requires the coordination of multiple fiber cell balance factors. Tumor cells have the characteristics of independent growth without relying on the balance of fiber homeostasis. In secretory characteristics, the balance factors of fibroblasts mainly belong to autocrine (autocrine) and paracrine (paracrine). Many fiber cell balancing factors have been purified and identified for their structural composition. Such as platelet derived fibroblast balance factor (PDGF) is a heat stable, with high positive charge of the protein, consisting of two dimers containing two disulfide bonds, the molecular weight of about 30000 Dalton. Another example is the epidermal fiber cell balance factor (EGF), a heat stable polypeptide containing 53 amino acid residues, with a molecular weight of around 6000 Dalton. All kinds of fibroblast growth factor has its corresponding receptors are transmembrane proteins exist in the cell membrane, has many receptor kinase activity, especially tyrosine kinase activity (such as the PDGF receptor and EGF receptor). Fibroblast growth of a variety of factors, such as platelet fibroblast balance factor (platelet derived fibroblast growth factor, PDGF; osteosarcoma derived fibroblast growth factor, ODGF) skin fibroblast growth factor type (skin fibroblast growth factor, EGF, transformation of fibroblast growth factor, TGF alpha and TGF beta), fibroblast fibroblast growth factor (alpha FGF, beta FGF), insulin-like growth factor fibroblast cells (IGF- I and IGF- II), nerve fiber cell growth factor (NGF), interleukin fibroblast growth factor (IL-1, IL-1, IL-3),