良性前列腺增生症合并糖尿病尿动力学特点分析.doc

良性前列腺增生症合并糖尿病的尿动力学特点分析 宗德斌1赵积晔 田兵 荆孝东 李猛 李勇 【摘要】 目的：探讨BPH合并糖尿病患者的尿动力学变化。方法：对45例BPH伴糖尿病患者和96例单纯性BPH患者进行尿动力学检测，并比较两组检测结果。结果：糖尿病组和对照组比较，最大尿流率、膀胱感觉功能、膀胱顺应性、排尿期最大逼尿肌压力及排尿后残余尿量与对照组比较差异有统计学意义(P0．05)。不稳定膀胱发生率方面差异无统计学意义(P0．05)。结论： BPH伴糖尿病患者膀胱功能障碍更严重，应尽早联合治疗，以避免延误病情。 【关键词】 糖尿病；尿动力学；良性前列腺增生症； Urodynamic studies on benign prostatic hyperplasia combined with diabetes mellitus ZONG de-bin, ZHAO ji-ye, TIAN bing, et al. Department of Urology Surgery, Dalian University Affiliated Xinhua Hospital, Dalian 116021, China Abstract： Objective To evaluate urinary dynamics effect on benign prostatic hyperplasia(BPH) patients accompanied with diabetic mellitus(DM). Methods A total of BPH patients with lower urinary tract symptoms were Studied. These patients were divided into 2 groups：Group A consisted of 96 BPH patients while Group B consisted of 45 BPH patients combined with DM．The results of urodynamic analysis between the two groups were compared．Between the two groups，there was significant difference in the maximum cystometry capacity，the value of bladder complicance,the maximum detrusor pressure during voiding and the postvoid residual Urine capacity(P0．05),While no significant differencethe in instability bladder．Conclusion The influence of DM on the function of the bladder in BPH patients is significant． h is important to decide which patient adapted to be operated and it may predict the prognosis of the operation by using the urodynamics study． 良性前列腺增生症(Benign Prostatic Hyperplasia，BPH)是引起中老年男性排尿障碍原因中最为常见的一种良性疾病。糖尿病神经源性膀胱尿道功能障碍是糖尿病引起的泌尿系统并发症，传统又称糖尿病膀胱病，40％一85％的糖尿病患者可并发此症【1】。随着社会的老龄化，临床医师越来越多地要面对BPH合并糖尿病的患者。目前关于BPH合并糖尿病患者的尿动力学改变研究较少。本研究对我院BPH合并糖尿病的患者进行回顾性分析，以探讨糖尿病对BPH的影响。以期为未来的BPH与糖尿病的防治提供新的观点和临床依据。 1 临床资料 1．1 2010年6月至20012年6月在大连大学附属新华医院泌尿外科行经尿道前列腺电切术(TURP)治疗的BPH患者141例，年龄55—91(64．34±6．24)岁；下尿路症状史2一15年，均行肛门指检、前列腺特异性抗原(PSA)、B超、静脉肾盂造影(IVU)及尿动力学检查和国际前列腺症状评分(international prostate symptom score，IPSS)，排除尿路感染及颅脑、脊髓等神经系统疾病病史。BPH合并糖尿病患者45例，单纯BPH患者96例对照。 1．2 检查方法 尿动力学仪检查项目：尿流率、同步膀