2-芳甲基-1H-苯并咪唑的熔融法合成 - 河北师范大学学报.PDF

36 / 1 / 河北师范大学学报/ / Vol. 36 No. 1 2012 1 JOURNALOFHEBEI NORMAL UNIVERSITY/ Natural Science Edition/ Ja n. 2012 2-芳甲基-1H-苯并咪唑的熔融法合成* 李英俊, 王雷雷, 孙淑琴 ( , 116029) 1 : 2-(1-)-1H-2--1H-, IR HNMR ., . ,, . :2--1H-; ; ; :O 622.3 :A :1000-5854(2012) 01-0059-03 Melting Synthesis of 2-arylmethy-l 1H-benzoimidazoles LI Yingjun, ANG Leilei, SUN Shuqin (School of Chemistry and Chemical Engineering,Liaoning NormalUniversity,Liaoning Dalian 116029,China) Abstract: Two 2-arylmethy-l 1H-benzoimidazole compounds were synthesized by the reaction of o- phenylenediaminewith 1-naphthylacetic acid or phenylacetic acid using a melting method, and their structures 1 were characterized by IR and HNMR spectra.The influences of the mole ratio of the reactants,the reaction time,the reaction temperature on the yieldwere investigatedand optimum experimental conditions werefound. Compared with the literature methods,this method has the advantagesof simple operation, short reaction time, easy purification,less by-products,higher yieldand green synthesis. Key words:2-arylmethy-l 1H-benzoimidazole; melting; synthesis; characterization 2--1H-,.2-( )-1H-AMPK(AMP ),Ò [1] ;2-(4-)-1H-(BBI) ( nAChRs) [2] A7,(AD) ;BBI [3] ; 2-(1-)-1H-2--1H-AMPK , [4] N-(APDM) , . 2--1H-4 : ¹ [5] [ 1] [6] ; º ; » [7]