老年间质性肺疾病（Interstitial lung disease in the elderly）.doc

老年间质性肺疾病（Interstitial lung disease in the elderly） Interstitial lung disease in the elderly Basic concept Pulmonary interstitium Composed of tissue located between alveoli. These organizational structures These include: alveolar wall, reticular and elastic fibers (connective tissue), Capillary network and lymphatic vessels. Lung parenchyma Mainly refers to the alveolar epithelium and alveolar cavity. * interstitial lung disease A class of diseases resulting from pulmonary interstitial lesions. This is a heterogeneous group of diseases involving the walls of the alveoli and surrounding alveoli. This disease occurs mainly in interstitial lung involvement, alveolar epithelial cells, pulmonary capillary endothelial cells and pulmonary arteriovenous. Generally around 60 years of age, male (29/10 million) slightly higher than women (27/10 million). The condition is progressive, with a 5 year survival rate of only 50% Common features of interstitial lung disease By clinical symptoms, chest imaging, pulmonary function and pathological changes are very similar: Exercise dyspnea; The chest phase showed diffuse interstitial infiltration on both sides; Limited ventilatory dysfunction and impaired diffusion function, abnormal PaO2 during rest or exercise; Histopathological features are inflammatory and fibrotic changes in the interstitium of the lung. ILD reasons - known causes: environmental / occupational related ILD Inorganic dusts (silicosis, asbestos, lung, etc.) Organic dust (exogenous allergic alveolitis) Gas / smoke (SO2, etc) Drug / therapy related ILD Antibiotics and chemical drugs (furan, etc.) Non steroidal anti-inflammatory preparation Cardiovascular drugs (amiodarone, etc.) Antineoplastic agents (bleomycin, etc) Illicit drugs (heroin, etc) ILD associated with lung infection Disseminated tuberculosis of blood type Viral pneumonia Pneumocystis carinii infection Chronic heart disease associated with ILD Left ventricular failure Left to right shunt ARDS recovery phase