基于椎管内微刺激的大鼠下肢运动脊髓功能核心区域测定.PDF

生物医学工程学杂志 2017年8月第34卷第4期 • 1 •   ·· 基于椎管内微刺激的大鼠下肢运动脊髓功能 核心区域测定 1 2 2 2 陈轶，马磊，杜薇，沈晓燕 1. 南通大学 医学院 生物医学工程系（江苏南通   226019 ） 2. 南通大学 电子信息学院 生物电子学系（江苏南通   226019 ） 【摘要】   为了提高基于脊髓功能性电激励重建后肢运动功能时电极植入位置的准确性和可靠性，实验测定 了大鼠下肢运动相关的脊髓功能核心区域的分布情况。此次研究利用三维扫描式椎管内微刺激技术对脊髓进行 刺激，以产生髋关节、膝关节和踝关节等下肢运动，并记录诱发这些运动的脊髓内坐标。为了克服个体间差异， 本文对 12 只 SD 大鼠的脊髓功能区域归一化后进行叠加，得到踝关节背屈、屈髋关节、伸髋关节和内收髋关节等 运动的脊髓功能核心区域。本研究为微电子神经桥接系统用于后肢运动功能的重建提供了参考。 【关键词】  椎管内微刺激；运动功能；功能性电激励；核心区域 Measuring the spinal cord functional core regions of hindlimb movements in rats with intraspinal microstimulation 1 2 2 2 CHEN Yi , Ma Lei , DU Wei , SHEN Xiaoyan 1. Department of Biomedical Engineering, School of Medicine, Nantong University, Nantong, Jiangsu 226019, P.R.China 2. Department of Bioelectronics, School of Electronic Information, Nantong University, Nantong, Jiangsu 226019, P.R.China Corresponding author: SHEN Xiaoyan, Email: xiaoyansho@ntu.edu.cn 【Abstract 】 In order to improve the accuracy and reliability of the electrodes implant location when using spinal functional electrical stimulation to rebuilding hindlimb motor function, we measured the distributions of spinal cord function core regions relatived with hindlimb movements. In this study, we utilized three-dimensional scanning intraspinal microstimulation technology to stimulate spinal cord to generate hip, knee and ankle joints movement, and acquired the coordinates of these movement in spinal cord. In this article, 12 SD rats were used to overcome individual differences. Motor function regions message of these rats were normalized and overlaid to obtain the spinal cord function co