α-受体阻滞剂加抗抑郁药治疗慢性前列腺炎疗效观察.docVIP

α-受体阻滞剂加抗抑郁药治疗慢性前列腺炎疗效观察【摘 要】 目的:观察α-受体阻滞剂加抗抑郁药治疗ⅢA、ⅢB型慢性前列腺炎的疗效,探讨α-受体阻滞剂加抗抑郁药在缓解ⅢA、ⅢB型慢性前列腺炎症状中的作用机制。方法:将166例ⅢA、ⅢB型慢性前列腺炎患者随机分为两组,观察组92例口服α-受体阻滞剂特拉唑嗪、抗抑郁药阿米替林、抗生素左氧氟沙星、维生素E、维生素C;对照组74例口服左氧氟沙星、维生素E、维生素C。两组各治疗6周,观察前列腺炎症状指标(NIH-CSPI)与前列腺液常规变化。结果:抗生素合用α-受体阻滞剂、抗抑郁药较单用抗生素更为有效。结论:α-受体阻滞剂加抗抑郁药可明显改善ⅢA、ⅢB型前列腺炎患者的症状。 【关键词】 前列腺炎; 受体阻滞剂; 抗抑郁药; 改善症状 Effect of α-receptor inhibitor combined with antidepressants on the treatment of chronic prostatitis ZHANG Renliang Department of Andrology, Changting Hospital of Women and Children’s Health, Fujian 366300, China 【Abstract】 Objectives: To observe the effect and mechanism of α-receptor inhibitor combined with antidepressants on the treatment of ⅢA、ⅢB chronic prostatitis. Methods: One hundred sixty-six chronic prostatitis patients type IIIA, IIIB were randomly divided into treatment group (92 cases) and control group (74 cases). The treatment group was treated with α-receptor inhibitor(terazosin) and antidepressants(amitriptyline), and antibiotics (levofloxacin), Vitamin E and C, while the control group was treated with levofloxacin, Vitamin E and C. The treatment lasted for 6 weeks to observe the change of NIH-CSPI index and prostate fluid. Results: Antibiotics combined with α-receptor inhibitor and anti-depressants are more effective in treating prostatitis than the mere use of antibiotics. Conclusion: α-receptor inhibitor combined with antidepressant could significantly improve the symptoms of IIIA and IIIB prostatitis patients. 【Key words】 Prostatitis; Receptor inhibitor; Antidepressant; Symptom improvement 慢性前列腺炎(以下简称CP)是男性常见病多发病,治疗手段多种多样,各有所长。抗生素、受体阻滞剂是目前很多男科医生认可的治疗用药。笔者根据CP患者的生理病理及心理特点,近4年来采取抗生素加受体阻滞剂及抗抑郁药的方法治疗92例ⅢA、ⅢB型CP患者取得较好疗效,现报告如下。 1 资料与方法 1.1 临床资料 本组166例,年龄22~48岁,平均31岁,病程3个月~4年,平均19个月。主诉有尿频、尿急、尿不尽或尿滴沥,会阴、下腹部或腹股沟疼痛不适,疲乏、失眠,性功能改变等。肛检22例前列腺两侧肌肉有压痛,前列腺按摩前尿常规检查阴性,前列腺按摩液镜检(EPS)15个/HP以下,按美国国立卫生院的慢性前列腺炎症状评分指数(NIH-CSPI)评分在15分以上,按美国国立卫生院慢性前列腺炎诊断标准诊断为ⅢA、ⅢB型CP。 1.2 方 法 166例CP患者随机分为观察组92例和对照组74例。观察组