特比萘芬与伊曲康唑meta分析.pdf

№删。．囊掰l盎需篇赣乎舞需鑫盏I 特比萘芬与伊曲康唑治疗甲真菌病疗效的Meta分析 谭方舒，杨崇艳，张宏 [摘要]目的系统评价特比萘芬与伊曲康唑治疗甲真茵病的有效性。方法计算机检索Cochrane图书馆、 Datebase，CNKI。纳入所有比较特比萘芬与伊曲康唑治疗甲真茵病的随机对照试 MEDLINE，Springer 验(RCT)。由2名研究者共同独立提取资料并评估纳入研究质量。采用Cochrane协作网提供的 RevMaM．2软件对试验数据进行统计分析。结果最终纳入6个RCT，其中4个特比萘芬250mg／d 连续疗法与伊曲康唑200ms／d连续疗法、2个特比萘芬250mg／d连续疗法与伊曲康唑400mg／d冲击 疗法治疗甲真茵病。Meta分析结果显示特比萘芬与伊曲康唑疗效的差异有统计学意义，合并后前者 康唑引起的严重系统性不良反应。结论现有临床证据表明，特比萘芬治疗甲真菌病的疗效优于伊 曲康唑。 [关键词】 甲真菌病；特比萘芬；伊曲康唑；Meta分析 756．4 [中图分类号】R 【文献标识码】A 【文章编号】1001—7089(2010)11-0989一03 oftheE丘敏嘣veofTerbinafmeVersusItraconazoleintheTreatmentof Meta-analysis Onychomycosis TAN Fang—shu，YANGChang-yan，ZHANGHong (DepartmentofDermatology，Frist够z泐甜HospitalofJinanUniversity，Guangzhou510632，China) [Correspondingauthor]ZHANGHong，E—mail：zhanghongen@126．com Toevaluatethe ofterbinafineanditraeonazoleinthetreatmentof [Abstract]Objective efficacy onychomycosis． MethodsTheelectronicdatabasesweresearchedfromtheCochrane Date- library。MEDLINE，Springer therandomizedcontrolled had the inthetreatment base。CNKI．AIl trials(RCT)whichcomparedefficacy of betweenterbinaftneanditraeonazolewereincludedintothis authors onychomycosis meta．analysis．Two reviewedthedataandassessedthe datawere and Revman4．2 independently quality．The inputanalyzedby Six RCTswere into ofthemwereeontinu— software．Resultshigh includedthis quality Meta．analysis．Four Otisterbinafineanditraconazoleandtheothertwowe