教材分析 金路捷联合神经节苷脂治疗新生儿缺血性脑病的疗效及相关讲述.PDFVIP

CHINESECOMMUNITY DOCTORS 论著·临床论坛 金路捷联合神经节苷脂治疗新生儿缺血性脑病的疗效 刘成胤 028400内蒙古开鲁县医院 doi:10.3969/j.issn.1007-614x.2015.8.41 摘 要 目的：探讨金路捷(鼠神经生长因子)联合神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法：2011年 1月-2014年2月收治HIE患者80例，随机分为治疗组44例，对照组36例，两组均给予常规治疗，纠正低氧血症及水 电解质紊乱，纠正低血糖及高血糖，控制惊厥和脑水肿，应用头部亚低温疗法等，治疗组在此基础上应用金路捷 20 μg加2mL生理盐水肌内注射，1次/d，疗程7～14d，神经节苷脂20～40mg/(kg·d)，用10%葡萄糖溶液30mL稀 释静滴1次/d，7～14d为1个疗程，比较两组总有效率、主要临床表现恢复时间。结果：两组总有效率、主要临床表现 恢复时间差异均有统计学意义(P＜0.01)，治疗组优于对照组。结论：金路捷联合神经节苷脂治疗HIE优于常规治疗。 关键词 金路捷；神经节苷脂；新生儿；缺氧缺血性脑损伤 TheeffectofJinLuJiecombinedwithgangliosideinthetreatmentofneonatalhypoxic-ischemicencephalopathy LiuChengyin KailuCountyHospitalofInnerMongolia028400 Abstract Objective:ToexplorethecurativeeffectofJinLuJie(mousenervegrowthfactor)combinedwithgangliosideinthe treatmentofhypoxicischemicencephalopathy(HIE).Methods:80HIEpatientswereselectedfromJanuary2011toFebruary2014. Theywererandomlydividedintothetreatmentgroupwith44casesandthecontrolgroupwith36cases.Thetwogroupsweregiven conventional treatment,correcting hypoxemia and water electrolysis disorder,correcting hypoglycemia and hyperglycemia, controlingconvulsionandbrainedema,applicationofheadmildhypothermiatherapy.Onthisbasis,thetreatmentgroupwasgiven JinLuJie 20 μgplus2 mLnormalsalineintramuscularinjection,onetimeoneday,thecourseoftreatmentwas 7 to 14days, ganglioside 20～40 mg/(kg·d),with 30 mL 10%glucoseattenuationquietdrop,onetimeoneday,7 to 14dayswasacourseof treatment.Thetotaleffectiveratesandtherecoverytimesofmainclinicalmanifestationsoftwogroupswerecompared.Results:The totaleffectiveratesandtherecoverytimesofmainclinicalmanifestationsoftwogroupshadsignificantdifferences(P＜0.01),and thetreatmentgroupwasbetterthanthecontrolgroup.Conclusion:JinLuJieandgangliosideinthetreatmentofHIEisbetterthan conventionaltherapy.