急性心肌梗死患者动态检测超敏C-反应蛋白临床意义.doc

急性心肌梗死患者动态检测超敏C-反应蛋白临床意义【摘要】 目的：探讨血清超敏C-反应蛋白（hs-CRP）水平变化与急性心肌梗死（AMI）时间的相关性以及对住院期间并发症的预测价值。方法：选取我院57名急性AMI住院患者及40名正常人，检测超敏C-反应蛋白（hs-CRP）、肌酸激酶（CK）及心肌同工酶（CK-MB）水平,进行对比分析,同时动态检测和观察CK-MB、hs-CRP峰值与AMI发生时间的关系。分析住院期间出现严重心功能不全、低血压、恶性心律失常的关联。结果：1. AMI患者组血清hs-CRP峰值主要分布在急性AMI发生48小时内,与AMI时间呈正相关,与对应CK-MB有良好相关性; 2. 急性AMI患者组血清hs-CRP（4.36±1.26 mg/L）与CK-MB ( 390.89±76.49)U/L,均显著高于正常成人组水平（P1=0.010、P2=0.001）； 3. 出现并发症的AMI患者hs-CRP水平(8.48±1.10mg/dl) 明显高于对照组水平(4.09±3.12mg/dl)。结论：血清超敏C-反应蛋白的升高与急性AMI的发生及预后存在密切关系。 【关键词】急性心肌梗塞；超敏C-反应蛋白 【Abstract】 AIM: Detect the change of the hs- CRP level after the occurrence of AMI. The value of hs- CRP to predict the complications of the AMI inpatients. METHODS : Select 57 AMI inpatients and 40 normal person . Detect the level of hs-CRP、CK and CK-Mb than analysis the data. Ambulatory monitoring the levels of CK-MB and hs-CRP after the occurrence of AMI . Observation the relationship between the peak level of CK-MB and hs-CRP and the AMI complications (serious cardiac insufficiency, low blood pressure, m alignant arrhythmia). RESULTS : 1、The peak level of the Hs - CRP is mainly below 48h after the occurrence AMI. It was positively associated with the time of AMI and well correlated with corresponding CK - MB level. 2、The level of hs-CRP（4.36±1.26 mg/L）and CK-MB ( 390.89±76.49U/L) in AMI group is obvious higher than control group （ P1=0.010、P2=0.001）. 3、The hs-CRP level in the AMI patients who occurrenced complications (8.48±1.10mg/dl)is significantly higher than the AMI patients who not occurrenced complications(4.09±3.12mg/dl) . CONCLUSIONS : The Hs - CRP is closely related with the occurrence and prognosis of AMI. 【KeyWords】Acute myocardial infarction 、Serum allergic c-reactive protein 【中图分类号】R524【文献标识码】B【文章编号】1005-0515(2011)04-0017-02 在我国冠心病发病率迅速上升,严重威胁人们的身体健康。冠心病的危险因素除已知的高血脂、高血压、吸烟、糖尿病、家族史、肥胖和缺乏运动之外，冠心病还有别的一些危险因素，近年来C反应蛋白（CRP）与冠心病的关系日益受到人们重视?? [1]。超敏C反应蛋白(hs-CRP)是急性时相蛋白，是反映炎性程度的敏感指标[2]。本研究通过动态检测急性心肌梗死（AMI）患者血清hs-CRP水平，旨在了解hs-CRP与AMI的相关性及对