某院围手术期抗菌药物应用研究.docVIP

某院围手术期抗菌药物应用研究【摘要】 目的:了解某院外科围手术期患者抗菌药物的应用情况。方法:对某院2010年1月~2010年10月的240例Ⅰ类手术围手术期的用药情况进行回归顾性调查分析。结果:Ⅰ类手术中头孢菌素类应用频率最高达77.08%,其次依次为青霉素类10.42%、克林霉素类7.08%、喹诺酮类5.42%。结论:该院围手术期抗菌药物选择合格率为55.42%,药物选择合格率过低,药物选择档次过高;预防性使用抗菌药物的时机合格率为47.92%,预防性使用抗菌药物时机合格率过低;术后抗菌药物使用时间平均79.20h,手术后预防性使用抗菌药物时间过长。应加强临床医务人员围手术期抗菌药物合理化使用的意识,有效地降低围手术期切口的感染率以及细菌耐药菌的发生率。 【关键词】围手术期;抗菌药物;应用分析 Analysis of the antimicrobial drug application in peroperative period Peng Lei?1 CHEN Long?2 GUAN Zhenshui?2 【Abstract】Objective: To investigate the application of antimicrobial drug use on the patients of the peroperative period in the hospital. Methods: Analyze the different drug use of 240 cases of type Ⅰ incision from January 2010 to October 2010. Results: The application of the highest frequency in type Ⅰ incision is cephalosporins 77.08%, followed by penicillins 10.42%, clindamycin class 7.08%, quinolones 5.42%. Conclusion: The qualification rate of antibiotic selection in peroperative period is 55.42%, the qualification rate of drug choice is too low, the choice of drugs level is too high; The timing of prophylactic use of antimicrobial agents in the qualification rate is 47.92%, the timing of prophylactic use of antimicrobial agents qualification rate is too low; Antimicrobial use after the operation time was 79.2hours average, prophylactic use of antibiotics after the operation time is too long. Perioperative awareness of rational use of antimicrobial agents of clinical medical staff should be enhanced in order to reduce the perioperative infection rate and incidence of resistant bacteria effectively. 【Key words】 perioperative period, antimicrobial drug, use analysis 【中图分类号】R952【文献标识码】A【文章编号】1005-0515(2010)011-0005-02 抗菌药物是临床应用广泛、品种较多、进展较快的一类药物,外科围手术期预防性使用抗菌药物是预防术后感染、增加治愈率的有效措施。但如果预防性使用抗菌药物的选择、使用时机、使用时间等方面出现不规范、不合理时可导致细菌耐药率的增加、药物不良反应甚至药源性疾病的发生以及浪费医疗卫生资源。2009年3月,卫生部办公厅再次发布《关于抗菌药物临床应用》管理有关问题的通知,为继续推进抗菌药物临床合理应用,根据2008年度全国抗菌药物临床应用监测与细菌监测结果。以严格控制Ⅰ类切口手术预防用药为重点,医疗机构要严格按照《抗菌药物临床应用指导原则》中围手术期患者抗菌药物预