143例乙型病毒性肝炎患者心电图及心肌酶谱研究.doc

143例乙型病毒性肝炎患者心电图及心肌酶谱研究[摘要] 目的 探讨乙型病毒性肝炎对心肌的影响。方法 对2002年2月～2008年10月浦江县人民医院收治的216例乙型病毒性肝炎患者进行常规心电图检查，有心电图异常者检测其心肌酶谱，并与35例正常对照组的心肌酶谱水平进行比较。 结果 216例患者中143例有心电图改变，以T波/S-T段改变、窦性心动过缓为多见。各型乙型病毒性肝炎患者的肌酸激酶及其同工酶、乳酸脱氢酶、天冬氨酸氨基转移酶、α-羟丁酸脱氢酶均有不同程度的升高，与正常对照组比较，差异有统计学意义（P＜0.01）。有心电图改变者与无心电图改变者病死率间差异有统计学意义（P＜0.01）。结论 乙型肝炎患者可发生心肌损伤，应加强检测心电图并予以保护心肌治疗。 [关键词] 乙型病毒性肝炎；心肌损害；心电图 [中图分类号] R512.6+2[文献标识码] B [文章编号] 1673-9701（2011）21-49-02 Analysis of Electrocardiogram and Myocardial Enzyme in 143 Cases with Hepatitis B Virus WU Suzhen Electrocardiographic Room of Pujiang People’s Hospital，Pujiang 322200，China [Abstract] Objective To investigate the influence of hepatitis B virus to myocardial. Methods From February 2002 to October 2008，in Pujiang people’s hospital 216 cases with hepatitis B virus were treated with routine cardiogram，the myocardial enzyme in patients with abnormal electrocardiographic were measured，and compared with 35 cases in the normal control group. Results In 216 case，143 cases had electrocardiogram changes，T wave/S-T segment changes and sinus bradycardia were seen. The creatine kinase and its isoenzymes，lactate dehydrogenase，aspartate amino shift enzyme，alpha hydroxyl butyrate dehydrogenases in patients with hepatitis B virus rise with different degree，there had significant difference compared with normal control group（P＜0.01）. The fatality ratio between ECG changes and no ECG changes had statistically significant difference（P＜0.01）. Conclusion Patients with hepatitis B virus may occur cardiac injury，we should strengthen electrocardiogram inspection and protect myocardial treatment. [Key words] Hepatitis B virus；Myocardial damage；Electrocardiogram 乙型肝炎病毒（HBV）感染呈世界性流行，据世界卫生组织报道，全球约20亿人曾感染过HBV，其中3.5亿为慢性HBV感染者。我国现有的慢性HBV感染者约9300万，其中慢性乙型肝炎患者约2000万例。乙型病毒性肝炎是一种全身感染性疾病，不但累及肝脏，而且会累及包括心脏在内的其他脏器。乙型病毒性肝炎患者并发心肌损伤在临床上较多见，并已成为患者死亡的常见原因之一。此研究对我院收治的乙型病毒性肝炎患者的心电图资料进行分析，以期了解乙型病毒性肝炎与心脏损害的关系。 1资料与方法 1.1一般资料 2002年2月～2008年10月浦江县人民医院收治乙型病毒性肝炎患者216例，其中男125例，女91例，年