0.5%5-氟尿嘧啶外敷及阴道填塞联合激光治疗女性多发尖锐湿疣74例临床疗效观察.doc

0.5%5-氟尿嘧啶外敷及阴道填塞联合激光治疗女性多发尖锐湿疣74例临床疗效观察【摘 要】 目的:观察采用0.5%5-氟尿嘧啶外敷及阴道填塞联合激光治疗女性多发尖锐湿疣的疗效。方法：74例女性多发尖锐湿疣患者分两组，分别采用0.5%5-氟尿嘧啶外敷及阴道填塞联合激光治疗和单纯采用CO?2激光治疗。结果：治疗组手术率下降28.9 %，手术面积缩小50%以上者达78.9%,治愈率达94.74%，复发率为5.26%；对照组治愈率76.31%，复发率为23.68%。结论：0.5%5-氟尿嘧啶外敷及阴道填塞联合激光治疗较单纯CO?2激光治疗效果明显，联合治疗方法可有效降低手术率、缩小手术面积，治愈率高、复发率低。 【关键词】 [CX2]尖锐湿疣； 0.5%5-氟尿嘧啶; 外敷; CO?2激光 External application of 0.5% 5-Fluorouracil combined with vaginal filling and laser irradiationin treatment of recurrent condyloma acuminatum: a report of 74 cases ZHENG Shuru, CHEN Xiaoyu Women and Children’s Health Clinic in Xiangcheng District, Fujian Zhangzhou 363000, China 【Abstract】 Objectives: Seventy-four cases of female recurrent condyloma acuminatum were divided into two groups. The experiment group was treated with 0.5% 5-Fluorouracil external application combined with vaginal filling and laser irradiation while the control group was only treated with CO?2 laser irradiation. Results: The surgery rate for the experiment group decreased by 28.9%. 78.9% patients decreased 50% of their surgery area. The curative rate was 94.74% for the experiment group and 76.31% for the control group. The recurrence rate was 5.26% for the experiment group and 23.68% for the control. Conclusion: External application of 0.5% 5-Fluorouracil combined with vaginal filling and laser irradiation can produce better effects than the single CO?2 laser irradiation treatment. The combined therapy can effectively reduce the surgery rate, narrow the surgery area, increase curative rate and decrease recurrence rate. 【Key words】 Condyloma acuminatum; 0.5% 5-Fluorouracil; External application; CO?2 laser radiation 近年来，尖锐湿疣的发病率有逐年增高的趋势，女性多发尖锐湿疣，尤其是位于尿道口、阴道壁、宫颈等处多发尖锐湿疣的治疗比较困难。笔者采用0.5%5-氟尿嘧啶外敷及阴道填塞联合激光治疗女性多发尖锐湿疣取得良好效果，现总结报告如下。 1 资料与方法 1.1 临床资料 74例女性患者均来自我科2000年1月~2010年1月收治的尖锐湿疣患者，年龄17～68岁，平均年龄30.4岁。病例入选标准：位于外阴尿道口、阴道口、大小阴唇、阴蒂、阴道壁、宫颈、肛门周围的菜花状、乳头状赘生物，数目较多（5个以上）、范围较广泛者。所有病例均经赘生物病理学检查，符合尖锐湿疣诊断,同时排除妊娠，严重肝、肾、心血管及造血系统疾病。随机分为治疗组38例，对照