251例药品不良反应报告研究.doc

251例药品不良反应报告研究[摘要] 目的:了解药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:收集我院2008年1月～2009年4月上报的251例ADR报表,按性别、年龄、给药途径、药品品种、ADR累及器官或系统及临床表现、ADR程度等进行统计分析。结果:ADR发生率中,50岁以上患者较高,占49.01%;抗感染药物引起的最高,占50.55%。ADR主要临床表现为皮肤及其附件损害,共122例,占48.61%。结论:医院应重视并做好ADR的监测、分析、评价工作,以保证药物治疗安全有效。 [关键词] 药品不良应;报告;统计;分析 [中图分类号]R969.3 [文献标识码] C[文章编号] 1673-7210(2010)01(a)-135-03 Analysis of 251 cases of adverse drug reactions reports in our hosipital LI Yue1, CHEN Bo2 (1.Department of Pharmacy, the People’s Hospital of Zhangqiu City, Zhangqiu 250200, China; 2.The Traditional Chinese Hospital of Zhangqiu City, Zhangqiu 250200, China) [Abstract] Objective: To investigate and to analyze the occurrence and the characteristics of adverse reactions of drugs in our hospital and to provide references for the rational use of drugs in the clinic. Methods: 251 cases of ADR reports collected from January 2008 to April 2009 in our hospital were analyzed statistically in terms of patients’ sex, age distribution, route of administration, drug varieties and ADR-involving organs/systems and clinical manifestations etc. Results: Patients over the age of 50 years shouted a higher incidence of ADR (49.01%), the anti-infective drugs showed the highest incidence rate of ADR(50.55%). The most common cilinical manifestations of ADR were the damage of skin and adnexa, 122 cases (48.61%). Conclusion: The hospitals should pay attention to the ADR monitoring, analysis, evaluation, and make sure the drug treatment is safe and effective. [Key words] Adverse drug reactions; Reports; Statistics; Analysis 随着对药品的进一步认识,人们对药品不良反应(ADR)也与对药品治疗作用一样越来越关注与重视,ADR监测工作已成为医院药事管理的重要内容。我院医、药、护各个层面都把发现药品ADR和及时上报药品ADR作为一项重要工作来对待。为全面了解ADR发生的规律并探讨其发生的原因,现将我院2008年1月～2009年4月上报的ADR报表进行回顾性整理分析,以增强临床医务人员的ADR监测意识,更好地促进临床合理用药。 1 资料与方法 收集我院2008年1月～2009年4月各科室上报的有效ADR报表251例,对患者的性别、年龄、给药途径、引起ADR的药品品种、ADR累及器官或系统及临床表现、ADR程度等进行统计,生成Excel表进行汇总分析。 2 结果 2.1 患者的性别、年龄分布与ADR的发生 251例报表中,男129例,占51.39%;女122例,占48.61%,性别无明显差异。年龄最大91岁,最小2个半月。患者年龄分布