VEGF-C及血VEGFR-3在直肠癌组织中表达及意义.doc

VEGF-C及血VEGFR-3在直肠癌组织中表达及意义[摘要] 目的 探讨血管内皮细胞生长因子-C与血管内皮生长因子受体-3在直肠癌中的表达及意义。方法 检测50例直肠癌患者的直肠远端切缘组织中的VEGF-C、VEGFR-3蛋白表达，并取50例正常直肠组织作对照。结果 直肠癌患者的癌组织中VEGF-C、VEGFR-3的表达要远高于正常对照组（P＜0.05），VEGF-C、VEGFR-3的表达与性别、分化程度、浸润深度无关（P＞0.05）；而与淋巴结转移、Dukes分期有关（P＜0.05）,且VEGF-C、VEGFR-3在直肠癌组织中的表达呈正相关。结论 VEGF-C、VEGFR-3在直肠癌组织中均呈高表达，二者的表达可能与直肠癌淋巴转移过程有关。 [关键词] 内皮细胞生长因子-C；血管内皮生长因子受体-3；直肠癌 [中图分类号]R735.3+7[文献标识码] B [文章编号] 1673-9701（2011）27-22-03 Expression and Its Clinical Significance of Vascular Endothelial Growth Factor-C and Vascular Endothelial Growth Factor Receptor-3 in Rectal Cancer Tissue WU WenhuiTANG YouzhenYANG ShibinXIAO Longbin Department of Gastrointestinal Surgery, Huangpu Hospital of the First Affiliated Hospital, SUN Yatsen University, Guangzhou 510700, China [Abstract] ObjectiveTo detect expression of vascular endothelial cell growth factor-C and vascular endothelial growth factor recipient-3 in rectal cancer tissue, and evaluate its clinical significance. Methods VEGF-C, VEGFR-3 protein express in distal margin tissue of tumor from fifty rectal cancer patients were detected, and were compared with 50 normal rectal tissues. Results The express of VEGF-C,VEGFR-3 in rectal cancer patients? tissue was much higher than that in normal rectal tissues（P＜0.05），the express of VEGF-C、VEGFR-3 has no relationship with gender, differentiation level, depth of infiltration（P＞0.05）, but related to lymph node metastasis, Dukes staging（P＜0.05）,expression of VEGF-C、VEGFR-3 in rectal cancer tissue showed positive correlation. Conclusion VEGF-C、VEGFR-3 in rectal cancer tissue shows high expression, and this might be linked to process of lymph node metastasis. [Key words] Vascular endothelial cell growth factor-C；Vascular endothelial growth factor recipient-3；Rectal cancer 直肠癌（rectal cancer）是胃肠道中最常见的恶性肿瘤，其发病率仅次于胃癌和食道癌。直肠癌常易发生转移，这也是其致死的主要原因，其主要转移途径为淋巴转移。近年来有报道称[1]，血管内皮细胞生长因子-C（VEGF-C）与血管内皮生长因子受体-3（VEGFR-3）可能在肿瘤的淋巴转移过程中起关键作用。为探讨它们与直肠癌淋巴转移的关系，本文特选择50例直肠癌患者石蜡标本，采用免疫组化法观察其远端组织中血管内皮